J
Jean-Pierre Vaerman
Researcher at Catholic University of Leuven
Publications - 157
Citations - 6600
Jean-Pierre Vaerman is an academic researcher from Catholic University of Leuven. The author has contributed to research in topics: Secretory component & Antibody. The author has an hindex of 44, co-authored 157 publications receiving 6414 citations. Previous affiliations of Jean-Pierre Vaerman include University of California, San Francisco & Cliniques Universitaires Saint-Luc.
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Journal ArticleDOI
The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA
Charlotte S. Kaetzel,Janet Robinson,Koteswara R. Chintalacharuvu,Jean-Pierre Vaerman,Michael E. Lamm +4 more
TL;DR: Using Madin-Darby canine kidney epithelial cells stably transfected with pIgR cDNA, soluble immune complexes (ICs) of 125I-labeled rat monoclonal antidinitrophenyl (DNP) dIgA and DNP/biotin-bovine serum albumin were transported from the basolateral to the apical surface and then released.
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Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling.
TL;DR: The ternary association of myosin Vb and Rab11-FIP2 with Rab11a suggests that a multimeric protein complex is involved in vesicle trafficking through plasma membrane recycling systems.
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Human antibody response to Clostridium difficile toxin A in relation to clinical course of infection.
TL;DR: Data suggest an association between a defective humoral response to toxin A and a more severe form of C. difficile infection and indicate that other host-related factors control the severity of CDAD and remain to be elucidated.
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Stimulation of secretory IgA and secretory component of immunoglobulins in small intestine of rats treated with Saccharomyces boulardii.
TL;DR: One of the mechanisms by which S. b.b. exerts its immunoprotective effect in the gastrointestinal tract is a stimulation of the intestinal secretion of s-IgA and of the secretory component of immunoglobulins, which is suggested to be due to an increase in enterocyte turnover rate.
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Rapid disappearance from serum of intravenously injected rat myeloma IgA and its secretion into bile
TL;DR: The rat liver is able to actively secrete a monoclonal IgA from the circulation into bile against a strong concentration gradient.