J
Jeanette Marjorie Wood
Researcher at Singapore Science Park
Publications - 180
Citations - 12079
Jeanette Marjorie Wood is an academic researcher from Singapore Science Park. The author has contributed to research in topics: Vascular endothelial growth factor & Angiogenesis. The author has an hindex of 57, co-authored 180 publications receiving 11694 citations. Previous affiliations of Jeanette Marjorie Wood include Karolinska Institutet & Johns Hopkins University.
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Journal ArticleDOI
Novel antiangiogenic effects of the bisphosphonate compound Zoledronic Acid
Jeanette Marjorie Wood,Karine Bonjean,Stephan Ruetz,Akeila Bellahcene,Laetitia Devy,Jean-Michel Foidart,Vincent Castronovo,Green Jonathan +7 more
TL;DR: It is shown that zoledronic acid has marked antiangiogenic properties that could augment its efficacy in the treatment of malignant bone disease and extend its potential clinical use to other diseases with an angiogenic component.
Journal ArticleDOI
Structure-based design of aliskiren, a novel orally effective renin inhibitor.
Jeanette Marjorie Wood,Jürgen Maibaum,Joseph Rahuel,Markus G. Grütter,N. C. Cohen,Vittorio Rasetti,Heinrich Rüger,Richard Dr. Göschke,Stefan Stutz,Walter Fuhrer,Walter Schilling,Pascal Rigollier,Yasuchika Yamaguchi,Frederic Cumin,Hans-Peter Baum,Christian Schnell,Peter Herold,Robert Mah,Chris Jensen,Eoin O'Brien,Alice Stanton,Martin P. Bedigian +21 more
TL;DR: Aliskiren is the first in a novel class of renin inhibitors with the potential for treatment of hypertension and related cardiovascular diseases and employs a combination of molecular modelling and crystallographic structure analysis to design renin inhibitor lacking the extended peptide-like backbone of earlier inhibitors.
Journal Article
VEGF is major stimulator in model of choroidal neovascularization.
TL;DR: Data suggest that VEGF signaling plays a critical role in the development of CNV in this model, and if safety is established, the effect of inhibiting V EGF receptor kinase activity should be investigated in patients with CNV.
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Renin inhibitors. Synthesis of transition-state analogue inhibitors containing phosphorus acid derivatives at the scissile bond.
TL;DR: The synthesis of five amino phosphorus derivatives, 1a-e, is described, which were incorporated into a series of analogues of the 5-14 portion of angiotensinogen, in most cases at the scissile Leu-Val bond to inhibit human plasma renin.
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Blockade of Vascular Endothelial Cell Growth Factor Receptor Signaling Is Sufficient to Completely Prevent Retinal Neovascularization
Hiroaki Ozaki,Man Seong Seo,Keiko Ozaki,Haruhiko Yamada,Eri Yamada,Naoyuki Okamoto,Francesco Hofmann,Jeanette Marjorie Wood,Peter A. Campochiaro +8 more
TL;DR: Three additional selective kinase inhibitors with different selectivity profiles are used to explore the signaling pathways involved in retinal NV and suggest that regardless of contributions by other growth factors, VEGF signaling plays a critical role in the pathogenesis ofretinal NV.