A dry powder medecine inhaler has an impeller (31) non-concentrically disposed in a mixing chamber (25). A motor spins the impeller at high speed. A plunger (106) introduces a dose of powdered medecine into the chamber so that all powder particles are available for intermixing disaggregation and comminution. An aperture (51) receives a first stream of air and passes it towards the mouthpiece for inhalation by the user. A wall (11) has at least one aperture (59) for diverting a portion of a main air stream into the aerosolizing chamber to mix with the particles to form a fine, low density, low velocity, dry mist of powdered medecine for inhalation by the user.

Dry powder inhaler

An apparatus including a first cartridge, a sensor, and a controller. The first cartridge can include a first release device configured to release a first substance into a housing. The controller can be configured to receive data from the sensor. The controller can determine an amount of first substance released by the first cartridge based on the data. The first release device can be controlled based on the determined amount of first substance.

Inhalation device including substance usage controls

The pulmonary route of administration has proven to be effective in local and systemic delivery of miscellaneous drugs and biopharmaceuticals to treat pulmonary and non-pulmonary diseases. A successful pulmonary administration requires a harmonic interaction between the drug formulation, the inhaler device, and the patient. However, the biggest single problem that accounts for the lack of desired effect or adverse outcomes is the incorrect use of the device due to lack of training in how to use the device or how to coordinate actuation and aerosol inhalation. This review summarizes the structural and mechanical features of aerosol delivery devices with respect to mechanisms of aerosol generation, their use with different formulations, and their advantages and limitations. A technological update of the current state-of-the-art designs proposed to overcome current challenges of existing devices is also provided.

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Inhalation drug delivery devices: technology update

Provided herein are methods, devices, systems, and computer readable medium for delivering one or more compounds to a subject. Also described herein are methods, devices, systems, and computer readable medium for transitioning a smoker to an electronic nicotine delivery device and for smoking or nicotine cessation.

Methods and devices for compound delivery

Inhaler comprising a body, at least one cap piece that is movable between a closed position and an open position, individual chambers formed on a chamber supporting member, movable supporting means (50) that take said chamber supporting member and are displaceable between a non-dispensing position and a dispensing position, a device for indicating doses dispensed or yet to be dispensed, said indicating device comprising a rotary indicating piece (127) having indicating means such as numbers, colours and/or symbols, and an actuator (160) operating in conjunction with said movable supporting means to turn said rotary indicating piece, when said movable supporting means return from the dispensing position to the non-dispensing position

Fluid Product Dispensing Device

The present invention includes dry powder inhalers for dispensing and/or holding inhalant formulated dry powder substances and associated fabrication and dispensing methods that can employ an amplitude modulated non-linear signal comprising a plurality of superimposed frequencies, the frequencies corresponding to a priori flow characteristic frequencies of the dry powder being dispensed. The present invention also includes pocket-sized inhalers with an elastomeric flexible pivoting cover.

Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages

Dry powder inhalers with a multi-dose dry powder package for dispensing pharmaceutical grade formulations of inhalable dry powder, include: (a) a blister package comprising a plurality of spaced apart sealed blisters thereon, each blister having a projecting ceiling and a floor defining a blister channel therebetween, the blister channel comprising a dry powder therein; (b) a movable blade cartridge holding a blade at a forward portion thereof; and (c) an extendable mouthpiece attached to the movable blade cartridge. In operation, a user pulls the mouthpiece outward and then pushes the mouthpiece inward to cause the blister package to advance to position a blister in a selected dispensing position in the inhaler and to cause the blade cartridge to move the blade across a blister ceiling held in the dispensing position in the inhaler to thereby open the blister held in the dispensing position.

Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances

Dry powder drug containment packages (25) with tab members (30) and meted dose sealed drug compartments (25d) can be used in an inhaler (10) having a flow chamber (40) with a hook member (50) that opens the drug compartments (25d) and/or a portion that flexes to vibrate the dry powder to facilitate fluidic active dispersion for inhalation.

Dry powder drug containment system packages with tabs, inhalers and associated methods

The disclosure describes methods and inhalers (50) that deagglomerate dry powder using inspiratory effort of a user of an inhaler (50). Inhaler fin (75) and mesh configurations are described that facilitate deagglomeration. At least in steady state conditions, a dry powder and airflow pattern can be generated having turbulence with flow vortices, some of which may have a vortex having an axis of rotation that extends in an inspiratory flow direction while others may have a vortex that is substantially orthogonal to the inspiratory flow direction in an inspiratory airflow path (12), as an amount of dry powder travels through the inhaler (50) to thereby deagglomerate the dry powder without trapping undue amounts of the dry powder during inhalation.

Dry Powder Inhalers that Inhibit Agglomeration, Related Devices and Methods

Dry powder inhalers (10) include: (a) a first generally planar spiral travel path (30) in an inhaler body, wherein the first spiral travel path has a plurality of adjacent curvilinear (30 ch) channels forming lanes with upstanding sidewalls, including an inner lane (30:) and an outer lane; and (b) a plurality of discrete sealed microcartridges (25) with substantially rigid bodies disposed in the first travel path, each comprising a pre-metered (typically dose) amount of dry powder, the microcartridges being configured to slidably advance along the first travel path toward an inhalation chamber that merges into an inhalation output port (10 p). In operation, at least one microcartridge is held in the inhalation chamber to release the dry powder therein during inhalation.

Jeffrey Alan Warden

Papers

Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages

Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances

Dry powder drug containment system packages with tabs, inhalers and associated methods

Dry Powder Inhalers that Inhibit Agglomeration, Related Devices and Methods

Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods