A dry powder medecine inhaler has an impeller (31) non-concentrically disposed in a mixing chamber (25). A motor spins the impeller at high speed. A plunger (106) introduces a dose of powdered medecine into the chamber so that all powder particles are available for intermixing disaggregation and comminution. An aperture (51) receives a first stream of air and passes it towards the mouthpiece for inhalation by the user. A wall (11) has at least one aperture (59) for diverting a portion of a main air stream into the aerosolizing chamber to mix with the particles to form a fine, low density, low velocity, dry mist of powdered medecine for inhalation by the user.

Dry powder inhaler

Inhaler comprising a body, at least one cap piece that is movable between a closed position and an open position, individual chambers formed on a chamber supporting member, movable supporting means (50) that take said chamber supporting member and are displaceable between a non-dispensing position and a dispensing position, a device for indicating doses dispensed or yet to be dispensed, said indicating device comprising a rotary indicating piece (127) having indicating means such as numbers, colours and/or symbols, and an actuator (160) operating in conjunction with said movable supporting means to turn said rotary indicating piece, when said movable supporting means return from the dispensing position to the non-dispensing position

Fluid Product Dispensing Device

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

Dry powder inhaler and system for drug delivery

A new dry powder inhaler is developed as a pulmonary medicine delivery device for dispersing precise tiny dosages (10 μg-50 mg) of pure carrier-free ultra-fine powdered medicament (<5 μm aerodynamics particle size) into a patient's lung. The powder is drawn from the blister cell and dispersed through an outlet tube assisted by two air streams. The first air stream goes through a the blister cell from its upstream side, to significantly fluidize the medicament in the dose to flow upward. The second one extracts the fluidized powder from downstream of the blister cell for further deagglomeration and dispersion of the medicament powder by shear force. The rotating multi-dose blister can hold up to 60 doses, which are pre-metered with pure ultra-fine powdered medicament. So that it has higher drug loading capability in small volumes, compared to most current dry powder inhalers, which usually use some excipient. The inhaler efficiently disperse the aerosolized medicament in the air stream to the deep interior of patient's lung. The fine particle fraction (<4.7 μm) is reported to reach as high as 80% using this inhaler.

Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.

Method for Improving the Pharmaceutic Properties of Microparticles Comprising Diketopiperazine and an Active Agent

Dry powder inhalers with a multi-dose dry powder package for dispensing pharmaceutical grade formulations of inhalable dry powder, include: (a) a blister package comprising a plurality of spaced apart sealed blisters thereon, each blister having a projecting ceiling and a floor defining a blister channel therebetween, the blister channel comprising a dry powder therein; (b) a movable blade cartridge holding a blade at a forward portion thereof; and (c) an extendable mouthpiece attached to the movable blade cartridge. In operation, a user pulls the mouthpiece outward and then pushes the mouthpiece inward to cause the blister package to advance to position a blister in a selected dispensing position in the inhaler and to cause the blade cartridge to move the blade across a blister ceiling held in the dispensing position in the inhaler to thereby open the blister held in the dispensing position.

Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances

Dry powder blister packages include sealed blisters that incorporate or cooperate with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.

Blister packages and associated methods of fabricating dry powder drug containment systems

Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.

Blister packages with frames and associated methods of fabricating dry powder drug containment systems

Blister packages with frames for dry powder drug containment

A lifting mechanism for a storage bin is positioned in a cabinet having a countertop. The lifting mechanism has a base adapted to be supported in the cabinet, a moveable member operably connected to the base, a support member connected to the moveable member, and a storage bin supported by the support member. The moveable member is moveable between a first position, wherein the storage bin is adapted to be positioned within the cabinet, and a second position wherein the storage bin is raised such that the storage bin is adapted to be positioned out of the cabinet. When the storage bin is raised, a top of the storage bin is adapted to be positioned proximate the countertop.

Paul Gilbert Rockwell

Papers

Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances

Blister packages and associated methods of fabricating dry powder drug containment systems

Blister packages with frames and associated methods of fabricating dry powder drug containment systems

Blister packages with frames for dry powder drug containment

Storage bin with lifting mechanism