J
Jeffrey D. Kent
Researcher at Pharmacia
Publications - 13
Citations - 3677
Jeffrey D. Kent is an academic researcher from Pharmacia. The author has contributed to research in topics: Valdecoxib & Adalimumab. The author has an hindex of 7, co-authored 13 publications receiving 3574 citations.
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Journal ArticleDOI
Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis: The CLASS Study: A Randomized Controlled Trial
Fred E. Silverstein,Gerald A. Faich,Jay L. Goldstein,Lee S. Simon,Theodore Pincus,Andrew Whelton,Robert W. Makuch,Glenn M. Eisen,Naurang M. Agrawal,William F. Stenson,Aimee M. Burr,William W. Zhao,Jeffrey D. Kent,James B. Lefkowith,Kenneth M. Verburg,G. Steven Geis +15 more
TL;DR: In this study, celecoxib, at dosages greater than those indicated clinically, was associated with a lower incidence of symptomatic ulcers and ulcer complications combined, as well as other clinically important toxic effects, compared with NSAIDs at standard dosages.
Journal ArticleDOI
The CHOICE trial: adalimumab demonstrates safety, fistula healing, improved quality of life and increased work productivity in patients with Crohn's disease who failed prior infliximab therapy
Simon Lichtiger,David G. Binion,Doug Wolf,Daniel H. Present,Arielle G. Bensimon,Eric Q. Wu,Andrew P. Yu,A. T. Cardoso,Jingdong Chao,Parvez Mulani,K. G. Lomax,Jeffrey D. Kent +11 more
TL;DR: Aliment Pharmacol Ther 2010; 32: 1228–1239.
Journal ArticleDOI
Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis.
David H Sikes,Naurang M. Agrawal,William W. Zhao,Jeffrey D. Kent,David P. Recker,Kenneth M. Verburg +5 more
TL;DR: The data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy.
Journal ArticleDOI
Valdecoxib does not impair platelet function.
TL;DR: Naproxen and diclofenac significantly reduced the platelet aggregation response to AA and to a lesser extent collagen and ADP at most assessments compared with placebo, and Valdecoxib may be a safer analgesic option than conventional NSAIDs in patients for whom bleeding complications are a concern.
Journal ArticleDOI
The COX-2 selective inhibitor, valdecoxib, does not impair platelet function in the elderly: results of a randomized controlled trial.
TL;DR: Valdecoxib's lack of effect on platelet aggregation and bleeding time suggests that it will have an improved clinical profile over nonselective NSAIDs, particularly in patients for whom bleeding complications are a concern.