J
Jeffrey H. Toney
Researcher at Kean University
Publications - 59
Citations - 2477
Jeffrey H. Toney is an academic researcher from Kean University. The author has contributed to research in topics: Beta-Lactamase Inhibitors & DNA. The author has an hindex of 21, co-authored 58 publications receiving 2369 citations. Previous affiliations of Jeffrey H. Toney include Northwestern University & Montclair State University.
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Journal ArticleDOI
Hydrolysis chemistry of the metallocene dichlorides M(η5-C5H5)2Cl2, M=Ti, V, Zr. Aqueous kinetics, equilibria, and mechanistic implications for a new class of antitumor agents
Jeffrey H. Toney,Tobin J. Marks +1 more
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Oleic acid and peanut oil high in oleic acid reverse the inhibitory effect of insulin production of the inflammatory cytokine TNF-α both in vitro and in vivo systems
Evros Vassiliou,Andres Gonzalez,Carmen García,James Tadros,Goutam Chakraborty,Jeffrey H. Toney +5 more
TL;DR: Oleic acid was found to be effective in reversing the inhibitory effect in insulin production of the inflammatory cytokine TNF-α, consistent with the reported therapeutic characteristics of other monounsaturated and polyunsaturated fatty acids.
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Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-β-lactamase
Jeffrey H. Toney,Paula M.D. Fitzgerald,Nandini Grover-Sharma,Steven H. Olson,Walter J. May,Jon G. Sundelof,Dana E. Vanderwall,Kelly A. Cleary,Stephan K. Grant,Joseph K. Wu,John W. Kozarich,David L. Pompliano,Gail G. Hammond +12 more
TL;DR: BPT inhibitors can sensitize a resistant B. fragilis clinical isolate expressing metallo-beta-lactamase to the antibiotics imipenem or penicillin G but not to rifampicin.
Journal ArticleDOI
Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase.
Jeffrey H. Toney,Gail G. Hammond,Paula M.D. Fitzgerald,Nandini Sharma,James M. Balkovec,Gregory P. Rouen,Steven H. Olson,Milton L. Hammond,Mark L. Greenlee,Ying-Duo Gao +9 more
TL;DR: Determination of high resolution crystal structures and molecular modeling of succinic acid inhibitor complexes with IMP-1 has allowed an understanding of the potency, stereochemistry, and structure-activity relationships of these inhibitors.
Journal Article
Clonal Variation of MCF-7 Breast Cancer Cells In Vitro and in Athymic Nude Mice
Katherine Seibert,Samir M. Shafie,Timothy J. Triche,Jacqueline Whang-Peng,Stephen J. O'Brien,Jeffrey H. Toney,Karen Huff,Marc E. Lippman +7 more
TL;DR: The allozyme phenotype at seven polymorphic human loci (allozyme genetic signature) demonstrated that the MCF-7 line and its derivatives were derived from the same individual and were distinct from the signatures of HeLa and a variety of other human breast cancer lines.