Showing papers by "Jeffrey M. Beekman published in 2010"

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Open Access

Journal Article•DOI•

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

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Jorg van Loosdregt, Yvonne Vercoulen¹, Teun Guichelaar, Yoony Y.J. Gent, Jeffrey M. Beekman¹, Olivier van Beekum², Arjan B. Brenkman², DirkJan Hijnen, Tuna Mutis, Eric Kalkhoven², Berent J. Prakken¹, Paul J. Coffer¹ - Show less +8 more•Institutions (2)

Boston Children's Hospital¹, University Medical Center Utrecht²

04 Feb 2010-Blood

TL;DR: Modulation of the acetylation state of Foxp3 provides a novel molecular mechanism for assuring rapid temporal control ofFoxp3 levels in T cells, thereby regulating Treg numbers and functionality and could provide a new therapeutic strategy to control inappropriate (auto)immune responses.

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337 citations