Showing papers by "Jeffrey M. Peters published in 1995"
TL;DR: Evidence is provided which suggests that Ahr mRNA and protein are present in mouse preimplantation embryos and results suggest that the embryo transcribes, rather than maternally--inherits Ahr RNA.
71 citations
TL;DR: A 4-h exposure to GSH prior to culture in Cd markedly improved embryo development suggesting that GSH taken up during pretreatment can provide protection against Cd-induced embryotoxicity, supporting the hypothesis that the developmental toxicity of Cd is in part due to oxidative damage that can be modulated by select antioxidants.
33 citations
TL;DR: Combined work shows that an antisense ODN against MT can significantly affect blastocyst formation of preimplantation embryos; some, but not all, of the observed effects on embryo cell number may have been due to nucleotide toxicity.
6 citations
TL;DR: Uterine 3H-estradiol binding in vitro was measured and was lower in LZ mice than in C and R mice; the reduction in binding was due to lower receptor number, and Zn deficiency can result in a reduction in uterine estradiol receptors and est radiol binding.
Abstract: To better define the mechanisms by which zinc (Zn) deficiency influences periconceptional development, we examined the effects of this developmental insult on uterine estrogen metabolism. CD-1 mice were assigned to 1 of 3 groups (Low Zn, LZ; Control, C; or Replete, R) and fed either a low Zn (⩽0.3 μg Zn/g) or control diet (47 μg Zn/g) 5 days prior to gestation day (GD) 0 and continuing up to GD 4 during early pregnancy. Mice in the R group were fed the low Zn diet until GD 1 after which they were fed the control diet. Uterine 3H-estradiol binding in vivo was measured on GD 2, GD 3, and GD 4. Binding was similar among groups on GD 2 and GD 3, but was lower on GD 4 in LZ mice than in C and R mice (61% of control value). On GD 4, uterine 3H-estradiol binding in vitro was measured and was lower in LZ mice than in C and R mice (63--74% of control values); the reduction in binding was due to lower receptor number. Thus, Zn deficiency can result in a reduction in uterine estradiol receptors and estradiol binding. © 1995 Wiley-Liss, Inc.
1 citations