J
Jennifer LeCouter
Researcher at Genentech
Publications - 23
Citations - 12608
Jennifer LeCouter is an academic researcher from Genentech. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor. The author has an hindex of 18, co-authored 23 publications receiving 11872 citations.
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Journal ArticleDOI
The biology of VEGF and its receptors.
TL;DR: Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions and is implicated in pathologicalAngiogenesis associated with tumors, intraocular neovascular disorders and other conditions.
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Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants.
Hendrik Gille,Joe Kowalski,Bing Li,Jennifer LeCouter,Barbara Moffat,Thomas F. Zioncheck,Nicolas Pelletier,Napoleone Ferrara +7 more
TL;DR: KDR-selective V EGF was also able to induce angiogenesis in the rat cornea to an extent indistinguishable from wild type VEGF, and it is demonstrated that KDR, but not Flt-1, stimulation is responsible for the induction of vascular permeability by VEGf.
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Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.
Jennifer LeCouter,Dirk R. Moritz,Bing Li,Gail Lewis Phillips,Xiao Huan Liang,Hans-Peter Gerber,Kenneth J. Hillan,Napoleone Ferrara +7 more
TL;DR: Selective activation of VEGF receptor–1 stimulated hepatocyte but not endothelial proliferation in vivo and reduced liver damage in mice exposed to a hepatotoxin, suggesting VEGFR-1 agonists may have therapeutic potential for preservation of organ function in certain liver disorders.
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Identification of an angiogenic mitogen selective for endocrine gland endothelium
Jennifer LeCouter,Joe Kowalski,Jessica Foster,Phil Hass,Zemin Zhang,Lisa Dillard-Telm,Gretchen Frantz,Linda Rangell,Leo Deguzman,Gilbert-Andre Keller,Franklin Peale,Austin L. Gurney,Kenneth J. Hillan,Napoleone Ferrara +13 more
TL;DR: Endocrine-gland-derived vascular endothelial growth factor (EG-VEGF), induced proliferation, migration and fenestration in capillary endothelial cells derived from endocrine glands, but had little or no effect on a variety of other endothelial and non-endothelial cell types tested.
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Mechanisms of age‐related macular degeneration and therapeutic opportunities
TL;DR: An overview of the underlying pathophysiology, risk factors, and driver molecular pathways in age‐related macular degeneration is provided.