G
Gilbert-Andre Keller
Researcher at Genentech
Publications - 22
Citations - 4259
Gilbert-Andre Keller is an academic researcher from Genentech. The author has contributed to research in topics: Vascular endothelial growth factor & Vascular endothelial growth factor A. The author has an hindex of 17, co-authored 22 publications receiving 4131 citations. Previous affiliations of Gilbert-Andre Keller include Howard Hughes Medical Institute.
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Journal ArticleDOI
The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.
TL;DR: VEGF associated with the ECM was bioactive, because endothelial cells cultured on ECM derived from cells expressing VEGF189 or V EGF206 were markedly stimulated to proliferate and can be released into a soluble and bioactive form by heparin or plasmin.
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VEGF is required for growth and survival in neonatal mice
Hans-Peter Gerber,Kenneth J. Hillan,Anne M. Ryan,Joe Kowalski,Gilbert-Andre Keller,Linda Rangell,Barbara D. Wright,Freddy Radtke,Michel Aguet,Napoleone Ferrara +9 more
TL;DR: Endothelial cells isolated from the liver of mFlt(1-3)-IgG-treated neonates demonstrated an increased apoptotic index, indicating that VEGF is required not only for proliferation but also for survival of endothelial cells.
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Identification of an angiogenic mitogen selective for endocrine gland endothelium
Jennifer LeCouter,Joe Kowalski,Jessica Foster,Phil Hass,Zemin Zhang,Lisa Dillard-Telm,Gretchen Frantz,Linda Rangell,Leo Deguzman,Gilbert-Andre Keller,Franklin Peale,Austin L. Gurney,Kenneth J. Hillan,Napoleone Ferrara +13 more
TL;DR: Endocrine-gland-derived vascular endothelial growth factor (EG-VEGF), induced proliferation, migration and fenestration in capillary endothelial cells derived from endocrine glands, but had little or no effect on a variety of other endothelial and non-endothelial cell types tested.
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In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells
Francis C. Zeigler,F. de Sauvage,HR Widmer,Gilbert-Andre Keller,Christopher J. Donahue,RD Schreiber,B. E. Malloy,Philip E. Hass,Dan L. Eaton,William Matthews +9 more
TL;DR: The experiments show that the megakaryocytopoietic and thrombopoetic activities of TPO are initiated at the level of an early progenitor cell or upon the hematopoietIC stem cell.
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Cu,Zn superoxide dismutase is a peroxisomal enzyme in human fibroblasts and hepatoma cells.
TL;DR: The intracellular localization of Cu,Zn superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) has been examined by immunofluorescence and immunocryoelectron microscopy of yeast cells expressing human Cu, Znsuperoxide dismUTase showed that the enzyme is translocated to the peroxisomes.