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Showing papers by "Jens Lagergren published in 2017"

Journal Article•DOI•
ADARs and editing: The role of A-to-I RNA modification in cancer progression.

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Kajsa Fritzell1, Li-Di Xu1, Jens Lagergren2, Marie Öhman1•
Stockholm University1, Royal Institute of Technology2
16 Nov 2017-Seminars in Cell & Developmental Biology
TL;DR: Depending on the cell type, cancer progression seems to mainly be induced by ADAR1 upregulation or ADAR2 downregulation, although in a few cases ADar1 is instead downregulated.

75 citations

Journal Article•DOI•
Fast and general tests of genetic interaction for genome-wide association studies

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Mattias Frånberg1, Mattias Frånberg2, Mattias Frånberg3, Rona J. Strawbridge1, Anders Hamsten1, Ulf de Faire1, Ulf de Faire4, Jens Lagergren5, Jens Lagergren6, Jens Lagergren3, Bengt Sennblad1, Bengt Sennblad3 •
Karolinska Institutet1, Stockholm University2, Science for Life Laboratory3, Karolinska University Hospital4, Royal Institute of Technology5, SERC Reliability Corporation6
06 Jun 2017-PLOS Computational Biology
TL;DR: Computationally efficient tests of interaction for the complete family of generalized linear models (GLMs) are presented and it is shown that jointly testing the full set of interaction parameters yields superior power and control of false positive rate.
Abstract: A complex disease has, by definition, multiple genetic causes. In theory, these causes could be identified individually, but their identification will likely benefit from informed use of anticipate ...

2 citations

Proceedings Article•DOI•
Abstract P6-01-04: Evolutionary analyses of matched primary and metastatic breast cancer reveal both linear and parallel progression with lack of axillary lymph node involvement

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Ikram Ullah, KG Muralidharan, Amjad Alkodsi, Una Kjällquist, Gustav Stålhammar, John Lövrot, NF Martinez, Jens Lagergren, Sampsa Hautaniemi, Johan Hartman, Jonas Bergh 
15 Feb 2017-Cancer Research
TL;DR: Evolutionary analyses of matched primary and metastatic breast cancer reveal both linear and parallel progression with lack of axillary lymph node involvement.
Abstract: Evolutionary analyses of matched primary and metastatic breast cancer reveal both linear and parallel progression with lack of axillary lymph node involvement

1 citations