Showing papers by "Jens Schmidt published in 2011"

TL;DR: It is found that tumor necrosis factor-α (TNF-α), a monokine overexpressed in inflammatory myopathies, led to a marked up-regulation of macroautophagy in skeletal myocytes, establishing a mechanism through which TNF- α regulates both macroautrophagy and MHC class II expression and suggesting that macroautophile-mediated antigen presentation contributes to the immunological environment of the inflamed human skeletal muscle.