The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

Albumin Fusion Proteins

2 – Isolation, Physicochemical Characterization, and Carbohydrate-Binding Specificity of Lectins

The invention describes albumin fusion proteins comprising growth hormone and serum albumin. The invention also describes nucleic acid molecules encoding the albumin fusion proteins of the invention, as well as vectors containing these nucleic acid molecules, host cells transformed with these vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally, the invention describes compositions comprising the albumin fusion proteins, and methods of treating patients in need of growth hormone, comprising administering the albumin fusion proteins of the invention.

Recombinant fusion proteins to growth hormone and serum albumin

Conformational analysis of furanoside-containing mono- and oligosaccharides.

Conformational analyses by molecular mechanics of two-bond linked, glucose-glucose and some glucose-fructose disaccharides are reviewed. Usually, the conformations found by diffraction studies of crystals of relevant molecules were in low-energy regions on φ,ψ surfaces computed with mm 3. However, several sucrosyl linkages had energies high above the global minimum. Also, the distributions of experimental conformations did not conform well to the energy surfaces for sucrose and, to a lesser extent, maltose. A new map for maltose, made with mm 3(92), had less low-energy area wherein crystal structures were not found, and a miniature crystal model accounts for the remaining distortions Of φ and ψ as well as the short O4…O1 distances in crystalline maltose. An internally consistent calculation of the lattice energy (−76kcalmor−1) required a dielectric constant of 2.5, and values around 3 also worked well for various intramolecular and intermolecular parameters and the φ,ψ map of maltose. The problems with sucrose were not resolved despite further study. The high molecular mechanics energy for some of the sucrosyl linkages may arise from failure to account for an overlapping exo-anomeric effect.

Jérôme Becquart

Papers

Structure cristalline d'une deuxième forme de mélézitose monohydrate. Effet de l'environnement sur la géométrie d'un oligosaccharide

Ultraviolet difference spectroscopy study of peanut lectin binding to mono- and disaccharides

Structure cristalline du 2-acétamido-1,3,6-tri-O-acétyl-2-désoxy-4-O-(2,3,4,6-tétra-O-acétyl-α-l-idopyranosyl)-α-d-glucopyranose