P
Pierre Sinaÿ
Researcher at École Normale Supérieure
Publications - 361
Citations - 11063
Pierre Sinaÿ is an academic researcher from École Normale Supérieure. The author has contributed to research in topics: Disaccharide & Glycosyl. The author has an hindex of 54, co-authored 361 publications receiving 10861 citations. Previous affiliations of Pierre Sinaÿ include University of Orléans & Pierre-and-Marie-Curie University.
Papers
More filters
Journal ArticleDOI
Structure-activity relationship in heparin : a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity
TL;DR: Results confirm that the synthetic pentasaccharide with the above structure corresponds to the actual minimal sequence required in heparin for binding to AT-III.
MonographDOI
Carbohydrates in chemistry and biology
TL;DR: This four-volume handbook presents an integrated and cutting-edge view of Glycoscience, and covers all chemical aspects, such as syntheses and analysis of carbohydrates and oligosaccharides, as well as the biological role and activity of oligosACcharides and carbohydrate/protein interactions.
Journal ArticleDOI
The structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence. Chemical and 13C nuclear-magnetic-resonance studies.
B. Casu,P Oreste,Giangiacomo Torri,G. Zoppetti,J Choay,J C Lormeau,Maurice Petitou,Pierre Sinaÿ +7 more
TL;DR: The chemical composition and the 13C n.r.p.m. spectra of heparin oligosaccharides, having high affinity for antithrombin III and high anti-(Factor Xa) activity, prepared by three independent approaches, have been studied and compared with those of the corresponding inactive species.
Journal ArticleDOI
Conformational flexibility: a new concept for explaining binding and biological properties of iduronic acid-containing glycosaminoglycans
TL;DR: Theoretical and experimental studies indicate that l-iduronic acid residues of glycosaminoglycans are in an equilibrium of different conformations, the relative proportion of conformers being a function of sulfation pattern and sequence.
Journal ArticleDOI
Conformer populations of L-iduronic acid residues in glycosaminoglycan sequences.
D. R. Ferro,Augusto Provasoli,Massimo Ragazzi,Benito Casu,Giangiacomo Torri,Veronique Bossennec,Bruno Perly,Pierre Sinaÿ,Maurice Petitou,Jean Choay +9 more
TL;DR: The 1H-n.r.m.O. 3J values for the L-iduronic acid (IdoA) residues for solutions in D2O of natural and synthetic oligosaccharides that represent the biologically important sequences of dermatan sulfate, heparan sulfates, and heparin have been rationalized by force-field calculations.