Showing papers by "Jerome R. Lechien published in 2016"
TL;DR: It is suggested that LC number is a significant and independent prognostic factor for HNSCC, which is higher in tumors and invaded lymph nodes than dysplastic lesions but it decreases in HPV-positive cancer patients.
43 citations
TL;DR: Acoustic parameters can help to better understand voice disorders in LPR and can be used as treatment outcomes in patients with roughness.
Abstract: Laryngopharyngeal reflux is a prevalent, not well-understood disease affecting a high proportion of patients who seek laryngology consultation. The objective of this prospective case series is to explore the subjective and objective voice modifications in Laryngopharyngeal reflux (LPR), especially the usefulness of acoustic parameters as treatment outcomes, and to better understand the pathophysiological mechanisms underlying the development of voice disorder. Forty-one patients with a reflux finding score (RFS) > 7 and a reflux symptom index (RSI) > 13 were enrolled and treated with pantoprazole 20 mg twice daily for three months. RSI, RFS, Voice Handicap Index (VHI), and Grade, Roughness, Breathiness, Asthenia, Strain and Instability (GRBASI) were assessed at baseline and after three months post-therapy. Acoustic parameters were measured by selecting the most stable interval of the vowel /a/. A study of correlations between acoustic measurements and laryngoscopic signs was conducted in patients with roughness. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS). Significant improvement in RSI, RFS, VHI, jitter, percent jitter, relative average perturbation (RAP), shimmer, percent shimmer, and amplitude perturbation quotient (APQ) was found at 3 months of treatment (p < .05). A correlation analysis revealed significant correlations between the grade of dysphonia, breathiness, asthenia, instability and jitter, percent jitter, RAP, shimmer, percent shimmer and APQ. In dividing our cohort into two groups of patients according to the presence of roughness, shimmer, percent shimmer and APQ significantly improved in patients with roughness, but no positive correlation was found between acoustic parameters and laryngoscopic signs. Acoustic parameters can help to better understand voice disorders in LPR and can be used as treatment outcomes in patients with roughness.
41 citations
TL;DR: The risk of death from HNSCC significantly increases when patients are exposed to tobacco and alcohol during their therapy, regardless of HPV status, as well as for consumers of alcohol and tobacco compared to nondrinkers.
Abstract: Purpose
Despite the advent of concomitant chemoradiotherapy (CCRT), the prognosis of advanced head and neck squamous cell carcinoma (HNSCC) patients remains particularly poor. Classically, HNSCC, especially oropharyngeal carcinomas, associated with human papillomavirus (HPV) exhibits better treatment outcomes than HNSCCs in non-infected patients, eliciting a call for the de-escalation of current therapies. To improve the management of HNSCC patients, we aimed to determine the impact of active HPV infection on patient response, recurrence and survival after CCRT in a population of heavy tobacco and alcohol consumers.
34 citations
2 citations
TL;DR: This poster presents a probabilistic procedure called “spot localization analysis” (SLA) which allows for the direct measurement of the response of the immune system to certain types of drugs.
Abstract: a EpiCURA Hospital, RHMS Baudour, Department of Otolaryngology and Head and Neck Surgery, Baudour, Belgium b University of Mons (UMONS), Faculty of Psychology, Research Institute for Language Sciences and Technology, Mons, Belgium c University of Mons (UMONS), Faculty of Medicine, Research Institute for Health Sciences and Technology, Laboratory of Anatomy and Cell Biology, Mons, Belgium d EpiCURA Hospital, RHMS Baudour, Department of Radiology, Baudour, Belgium
2 citations
05 Dec 2016
TL;DR: A selection system after MED1, based on medical courses, inter alia, could speed up the maturation of students and show a moderate link between success in MED1 and success inMED6, as long as the students undergo selection.
Abstract: Objectives . To determine the impact of gender on success of students studying Medicine in Belgium from the first year (MED1) to the sixth year (MED6) of training, in the context (or not) of a selection process after three years at university. Subjects and method . Data were evaluated from two cohorts of medical students: students of the first group (n=88) were not submitted to a selection process and students of the second group (n=76) were submitted to a selection process after MED3. Students were enrolled in Brussels Medical School. The variables studied were the grades obtained after the first session of exams, and the student’s gender. Variables were put into perspective in relation to the cohort/study year. STATA software was used for statistical analysis. Results . Linear regression showed the significant predictability of the grade obtained in MED2 for the grade obtained in MED6 for males and females only in the context of selection (r=0.51; p<0.001). The impact of grades after three years on those after six years was negative in the first group of students (r=-0.17; p=0.005) and positive in the second group (r=0.54; p<0.001). Conclusion . These results show a moderate link between success in MED1 and success in MED6, as long as the students undergo selection. A selection system after MED1, based on medical courses, inter alia, could speed up the maturation of students. Further studies with a higher number of candidates are necessary to confirm these results.
2 citations