J
Jesi Y. To
Researcher at University of Rochester
Publications - 3
Citations - 51
Jesi Y. To is an academic researcher from University of Rochester. The author has contributed to research in topics: Chemokine receptor & Chemokine. The author has an hindex of 3, co-authored 3 publications receiving 37 citations.
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Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ
TL;DR: Examination of the relative roles of Gαi and Gβγ activation in the migration of neutrophils on surfaces coated with the integrin ligand intercellular adhesion molecule–1 (ICAM-1) and the small molecule 12155 provides evidence for a direct role of activated G αi in promoting cell polarization through a cAMP-dependent mechanism and in inhibiting adhesion through acAMP-independent mechanism.
Journal ArticleDOI
Inhibition of G Protein βγ Subunit Signaling Abrogates Nephritis in Lupus‐Prone Mice
Javier Rangel-Moreno,Jesi Y. To,Teresa Owen,Bruce I. Goldman,Alan V. Smrcka,Jennifer H. Anolik +5 more
TL;DR: This study concludes that inhibition of Gβγ signaling ameliorates disease in a mouse model of SLE through inhibition of chemokine receptor signal transduction.
Journal ArticleDOI
Activated heterotrimeric G protein αi subunits inhibit Rap-dependent cell adhesion and promote cell migration.
TL;DR: It is proposed that the dynamic spatiotemporal balance between Gβγ-promoted adhesion and Gαi-GTP reversal of adhesion is important for this process of cell migration, which involves cycles ofAdhesion and de-adhesion.