S
Sundeep Malik
Researcher at University of Rochester
Publications - 26
Citations - 1378
Sundeep Malik is an academic researcher from University of Rochester. The author has contributed to research in topics: Phospholipase C & Protein subunit. The author has an hindex of 15, co-authored 22 publications receiving 1205 citations.
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Journal ArticleDOI
Differential Targeting of Gßγ-Subunit Signaling with Small Molecules
Tabetha M. Bonacci,Jennifer L. Mathews,Chujun Yuan,David M. Lehmann,Sundeep Malik,Dianqing Wu,Jose L. Font,Jean M. Bidlack,Alan V. Smrcka +8 more
TL;DR: Virtual docking of a small-molecule library to a site on Gβγ subunits that mediates protein interactions is performed to demonstrate an approach for modulation of G protein–coupled receptor signaling that may represent an important therapeutic strategy.
Journal ArticleDOI
Epac and Phospholipase Cϵ Regulate Ca2+ Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II
Emily A. Oestreich,Sundeep Malik,Sanjeewa A. Goonasekera,Burns C. Blaxall,Grant G. Kelley,Robert T. Dirksen,Alan V. Smrcka +6 more
TL;DR: It is demonstrated that PLC ϵ phosphatidylinositol 4,5-bisphosphate hydrolytic activity and PLCϵ-stimulated Rap1 GEF activity are both required for PLC⩽-mediated enhancement of sarcoplasmic reticulum Ca2+ release and that P LCϵ significantly enhances Rap activation in response to βAR stimulation in the heart.
Journal ArticleDOI
Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes.
Emily A. Oestreich,Huan Wang,Sundeep Malik,Katherine A. Kaproth-Joslin,Burns C. Blaxall,Grant G. Kelley,Robert T. Dirksen,Alan V. Smrcka +7 more
TL;DR: A novel endogenous PKA-independent βAR-signaling pathway through cAMP-dependent Epac activation, Rap, and PLCϵ that enhances intracellular Ca2+ release in cardiac myocytes is defined.
Journal ArticleDOI
Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.
Lianghui Zhang,Sundeep Malik,Jinjiang Pang,Huan Wang,Keigan M. Park,David I. Yule,Burns C. Blaxall,Alan V. Smrcka +7 more
TL;DR: It is concluded that perinuclear PLCε, scaffolded to mAKAP in cardiac myocytes, responds to hypertrophic stimuli to generate diacylglycerol from PI4P in the Golgi apparatus, in close proximity to the nuclear envelope, to regulate activation of nuclear PKD and hypertrophic signaling pathways.
Journal ArticleDOI
Phospholipase C∈ Scaffolds to Muscle-specific A Kinase Anchoring Protein (mAKAPβ) and Integrates Multiple Hypertrophic Stimuli in Cardiac Myocytes
TL;DR: It is proposed that PLCϵ integrates multiple upstream signaling pathways to generate local signals at the nucleus that regulate hypertrophy.