J
Jesse R. Zamudio
Researcher at University of California, Los Angeles
Publications - 24
Citations - 1872
Jesse R. Zamudio is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: RNA & Messenger RNA. The author has an hindex of 14, co-authored 21 publications receiving 1574 citations. Previous affiliations of Jesse R. Zamudio include University of California & Massachusetts Institute of Technology.
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Journal ArticleDOI
LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint
Nadya Dimitrova,Jesse R. Zamudio,Robyn M. Jong,Dylan S. Soukup,Rebecca Resnick,Kavitha Sarma,Amanda J. Ward,Arjun Raj,Jeannie T. Lee,Phillip A. Sharp,Tyler Jacks +10 more
TL;DR: In this paper, the p53-regulated long noncoding RNA lincRNA-p21 has been shown to act in trans via several mechanisms ranging from repressing genes in the P53 transcriptional network to regulating mRNA translation and protein stability.
Journal ArticleDOI
Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition
TL;DR: Quantification of cellular miRNA and mRNA/ncRNA target pool levels indicates that miRNA:target pool ratios and an affinity partitioned target pool accurately predict in vivo Ago binding profiles and miRNA susceptibility to target competition.
LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint
Kavitha Sarma,Jeannie T. Lee,Nadya Dimitrova,Jesse R. Zamudio,Robyn M. Jong,Dylan S. Soukup,Rebecca Resnick,Amanda J. Whipple,Arjun Raj,Phillip A. Sharp,Tyler Jacks +10 more
TL;DR: Findings indicate that lincRNA-p21 affects global gene expression and influences the p53 tumor suppressor pathway by acting in cis as a locus-restricted coactivator for p53-mediated p21 expression.
Journal ArticleDOI
Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome
TL;DR: Data show divergent polymerases are regulated after P-TEFb recruitment with uaRNA levels controlled by the exosome, and Isg20l1 induction reveals equivalent increases in transcriptional activity in sense and antisense directions.
Journal ArticleDOI
2′-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family
Maria Werner,Elzbieta Purta,Katarzyna Kamińska,Iwona A. Cymerman,David A. Campbell,Bidyottam Mittra,Jesse R. Zamudio,Nancy R. Sturm,Jacek Jaworski,Janusz M. Bujnicki +9 more
TL;DR: The validation of a human enzyme that methylates the ribose of the second transcribed nucleotide encoded by FTSJD1 is reported, henceforth renamed HMTR2 to reflect function.