J
Jessica C. Greene
Researcher at University of Washington
Publications - 4
Citations - 1775
Jessica C. Greene is an academic researcher from University of Washington. The author has contributed to research in topics: Parkin & Genetic screen. The author has an hindex of 4, co-authored 4 publications receiving 1645 citations.
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Journal ArticleDOI
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants.
Jessica C. Greene,Alexander J. Whitworth,Isabella Kuo,Laurie A. Andrews,Mel B. Feany,Leo J. Pallanck +5 more
TL;DR: It is indicated that the tissue-specific phenotypes observed in Drosophila parkin mutants result from mitochondrial dysfunction and raise the possibility that similar mitochondrial impairment triggers the selective cell loss observed in AR-JP.
Journal ArticleDOI
Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease.
Alexander J. Whitworth,Dorothy A. Theodore,Jessica C. Greene,Helen Beneš,Paul D. Wes,Leo J. Pallanck +5 more
TL;DR: It is shown that Drosophila parkin mutants display degeneration of a subset of dopaminergic neurons in the brain, suggesting that the mechanism of DA neuron loss in Drosophon mutants is similar to the mechanisms underlying sporadic Parkinson's disease.
Journal ArticleDOI
Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis
TL;DR: In this paper, Parkin function in the fruit fly Drosophila melanogaster was studied and it was shown that loss-of-function mutations in oxidative stress components enhance the parkin mutant phenotypes.
Journal ArticleDOI
A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage.
Stephen M. Jackson,Alexander J. Whitworth,Jessica C. Greene,Randell T. Libby,Sandy L. Baccam,Leo J. Pallanck,Albert R. La Spada +6 more
TL;DR: Drosophila is used to model expanded CAG repeat instability by creating transgenic flies carrying trinucleotide repeat expansions, and it is found that SCA7 CAG90 repeats are stable in DrosophILA, regardless of context.