J
Jessica H. Spitzer
Researcher at National Institutes of Health
Publications - 4
Citations - 1637
Jessica H. Spitzer is an academic researcher from National Institutes of Health. The author has contributed to research in topics: TLR4 & T cell. The author has an hindex of 4, co-authored 4 publications receiving 1581 citations.
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Journal ArticleDOI
Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism
Alessandra Mazzoni,Vincenzo Bronte,Alberto Visintin,Jessica H. Spitzer,Elisa Apolloni,Paolo Serafini,Paola Zanovello,David M. Segal +7 more
TL;DR: It is shown that the MSC lines potently block in vitro proliferation of T cells stimulated with either mitogen or antigenic peptide, with as few as 3% of MSC cells causing complete suppression.
Journal ArticleDOI
Regulation of Toll-like receptors in human monocytes and dendritic cells.
Alberto Visintin,Alessandra Mazzoni,Jessica H. Spitzer,David H. Wyllie,Steven K. Dower,David M. Segal +5 more
TL;DR: TLRs are expressed in iDC and are involved in responses to at least one pathogen-derived substance, LPS, and its extremely low surface expression implies that it is a very efficient signal transducer in i DC.
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Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization.
TL;DR: It is proposed that the Th2 cells favor IgE production, leading to increased histamine secretion by mast cells, thus creating a positive feedback loop that could contribute to the severity of atopic diseases.
Journal ArticleDOI
Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells
TL;DR: TLR1 might restrain potentially dangerous innate response to LPS by binding to TLR4 and preventing the formation of active signaling complexes, which are essential for LPS‐induced septic shock.