Jessica Heidrich

TL;DR: Results provide evidence that hPAR and PXR.1 may represent orthologous genes from different species that have evolved to regulate overlapping target genes in response to pharmacologically distinct CYP3A activators, and have potential implications for the in vitro identification of drug interactions important to humans.

TL;DR: The results show that exendin‐4 is able to promote adult neurogenesis in vitro and in vivo, normalize dopamine imbalance, and increase the number of cells positive for markers of dopaminergic neurons in the substantia nigra in a model of Parkinson's disease.

TL;DR: In this paper, the authors proposed methods of promoting neurogenesis by contacting neuronal tissue with neuro-genesis modulating agents, and proposed novel methods for treating neurological disorders using neurogenescoding agents.

TL;DR: It is concluded that PACAP, through PAC1, is a potent mediator of adult neural stem cell proliferation and ex novo in vitro formation of multipotent neurospheres with the capacity to generate both neuronal and glial cells.

TL;DR: A series of 5-substituted 2-benzoylaminobenzoic acids synthesized and assayed for PPARalpha/gamma activity was shown to activate the PPARgamma receptor through interaction with a novel binding site.