Jessica S. Damoiseaux

TL;DR: Findings show that the baseline activity of the brain is consistent across subjects exhibiting significant temporal dynamics, with percentage BOLD signal change comparable with the signal changes found in task-related experiments.

TL;DR: This work examined the functional properties of brain networks based on spontaneous fluctuations within brain systems using functional magnetic resonance imaging to hypothesized that functional connectivity of intrinsic brain activity in the "default-mode" network (DMN) is affected by normal aging and that this relates to cognitive function.

TL;DR: This review aims to examine how the understanding of the relationship between structure and function in the ‘resting’ brain has advanced over the last several years and discusses eight articles that directly compare resting-state functional connectivity with structural connectivity and three clinical case studies of patients with limited white matter connections between the cerebral hemispheres.

TL;DR: Evidence is presented of AD-induced changes in global brain functional connectivity specifically affecting long-distance connectivity, which supports the anterior-posterior disconnection theory and its role in AD.

TL;DR: The results suggest that earlier in the disease, regions of the posterior default mode network start to disengage whereas regions within the anterior and ventral networks enhance their connectivity, however, as the disease progresses, connectivity within all systems eventually deteriorates.