https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

Plants used against cancer - an extension of the work of Jonathan Hartwell.

Isoflavonoids of the leguminosae

Traditional herbal medicines have been reported to possess significant bioactivities. In this investigation, a combined strategy using both phytochemical and biological approaches was conducted to discern the effective components of licorice, a widely used herbal medicine. Altogether, 122 compounds (1–122), including six new structures (1–6), were isolated and identified from the roots and rhizomes of Glycyrrhiza uralensis (licorice). These compounds were then screened using 11 cell- and enzyme-based bioassay methods, including Nrf2 activation, NO inhibition, NF-κB inhibition, H1N1 virus inhibition, cytotoxicity for cancer cells (HepG2, SW480, A549, MCF7), PTP1B inhibition, tyrosinase inhibition, and AChE inhibition. A number of bioactive compounds, particularly isoprenylated phenolics, were found for the first time. Echinatin (7), a potent Nrf2 activator, was selected as an example for further biological work. It attenuated CCl4-induced liver damage in mice (5 or 10 mg/kg, ip) and thus is responsible, at...

Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine

Natural products remain an important source of new drugs, new drug leads and new chemical entities. The plant based drug discovery resulted mainly in the development of anticancer agents including plants (vincristine, vinblastine, etoposide, paclitaxel, camptothecin, topotecan and irinotecan), marine organisms (citarabine, aplidine and dolastatin 10) and micro-organisms (dactinomycin, bleomycin and doxorubicin). Beside this there is numerous agents identified from fruits and vegetables can used in anticancer therapy. The agents include curcumin (turmeric), resveratrol (red grapes, peanuts and berries), genistein (soybean), diallyl sulfide (allium), S-allyl cysteine (allium), allicin (garlic), lycopene (tomato), capsaicin (red chilli), diosgenin (fenugreek), 6-gingerol (ginger), ellagic acid (pomegranate), ursolic acid (apple, pears, prunes), silymarin (milk thistle), anethol (anise, camphor, and fennel), catechins (green tea), eugenol (cloves), indole-3-carbinol (cruciferous vegetables), limonene (citrus fruits), beta carotene (carrots), and dietary fiber. In this review active principle derived from natural products are offering a great opportunity to evaluate not only totally new chemical classes of anticancer agents, but also novel lead compound and potentially relevant mechanisms of action. Keywords: Cancer, vincristin, vinblastin, fruit, vegetables.

http://www.arjournals.org/index.php/ijpm/article/download/278/295

Natural sources as potential anti-cancer agents: A review

Chromenes from Evodia lepta

Two isoprenoid-substituted isoflavans from roots of Maackia tenuifolia

Three prenylated isoflavans from Maackia tenuifolia

Three New isoflavans, manuifolin G, H and K were isolated from roots of Maackia tenuifolia . Their structures were established as (3 R )-5′-(1,1-dimethyl-2-propenyl)-8-(3-hydroxy-3-methylbutyl)-7-2′,4′-trihydroxyisoflavan, (3 R )-6-(3-methyl-2-butenyl)-7,2′,4′-trihydroxyisoflavan and (3 R )-5′-(1,1-dimethyl-2-propenyl)-7,2′,4′-trihydroxyisoflavan by spectroscopic methods.

Jia-Feng Zeng

Papers

Chromenes from Evodia lepta

Two isoprenoid-substituted isoflavans from roots of Maackia tenuifolia

Three prenylated isoflavans from Maackia tenuifolia

Three Prenylated Isoflavans from Maackia tenuifolia.