J
Jia Wang
Researcher at Chinese Academy of Sciences
Publications - 3
Citations - 62
Jia Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Kinase & Triazine. The author has an hindex of 3, co-authored 3 publications receiving 60 citations.
Papers
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Journal ArticleDOI
WJD008, a Dual Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin Inhibitor, Prevents PI3K Signaling and Inhibits the Proliferation of Transformed Cells with Oncogenic PI3K Mutant
Ting Li,Jia Wang,Xiang Wang,Na Yang,Si-meng Chen,Linjiang Tong,Chunhao Yang,Linghua Meng,Jian Ding +8 more
TL;DR: WJD008 is a potent dual PI3K/mTOR modulator with antiproliferative and anticlonogenic activity in tumor cells and transformed cells with PIK3CA mutant, which provides new clues for the design and development of this chemical scaffold as an anticancer drug.
Journal ArticleDOI
Discovery and bioactivity of 4-(2-arylpyrido[3′,2′:3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitors
Jia Wang,Xiang Wang,Yanhong Chen,Si-meng Chen,Guang Chen,Linjiang Tong,Linghua Meng,Yuyuan Xie,Jian Ding,Chunhao Yang +9 more
TL;DR: Four compounds designed and synthesized 4-(2-arylpyrido[3',2':3,4]pyrrolo[1,2-f]triazin-4-yl)morpholine derivatives showed selectivity over 15 tested protein kinases and anti-proliferative activity at micromolar concentration against several cancer cell lines.
Patent
Pyrido-pyrrole triazine compound, and preparation method and application thereof
TL;DR: In this paper, a dual inhibitor of a pyrido-pyrrole triazine compound with a structure shown in general formula I is described. But the authors do not discuss the application of the dual inhibitor in the treatment of cancer.