Jian Cheng

TL;DR: This minireview highlights the recent achievements of NO-releasing macromolecules in terms of chemical design and biomedical applications and hopes that more efforts could be devoted to this emerging yet promising field.

TL;DR: It is demonstrated that BM can simultaneously scavenge overproduced NO and attenuate proinflammatory cytokines in lipopolysaccharide (LPS)-challenged macrophage cells, and provides new insights into artificial BM for potential biomedical applications.

TL;DR: In this article, non-metallic CO-releasing micelles were developed via a photooxygenation mechanism of 3-hydroxyflavone derivatives, enabling CO release under red light irradiation (e.g., 650 nm).

TL;DR: The localized CO delivery of CORPs by taking advantage of the spatiotemporal control of light stimulus outperformed conventional metal carbonyls such as CORMs in terms of anti-inflammation and cutaneous wound healing and opens a novel avenue toward metal-free CORPs for potential biomedical applications.

TL;DR: This work devise a macromolecular NO donor by integrating photoresponsive N,N'-dinitroso-p-phenylenediamine derivatives into the middle block of an amphiphilic triblock copolymer and the photo-mediated NO release process transforms the DNP to quinondimine (QDI) moieties, enabling the degradation of the resulting polymers due to the spontaneous hydrolysis of QDI moieties.