Jian He

TL;DR: The STAMPs presented here are capable of eliminating S. mutans from multispecies biofilms without affecting closely related noncariogenic oral streptococci, indicating the potential of these molecules to be developed into “probiotic” antibiotics which could selectively eliminate pathogens while preserving the protective benefits of a healthy normal flora.

TL;DR: The successful creation of the first synthetic, target-specific antimicrobial peptide, G10KHc, is reported, via addition of a rationally designed Pseudomonas-specific targeting moiety (KH) to a generally killing peptide (novispirin G10).

TL;DR: In this paper, in various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species, and the chimeric peptide is used to provide novel targeted antimicrobial compositions.

TL;DR: Several small (<25aa) peptides have been designed based on the sequence of the dentin phosphoprotein, one of the major noncollagenous proteins thought to be involved in the mineralization of the Dentin extracellular matrix during tooth development and binding to calcium phosphate compounds and to hydroxyapatite surfaces.

TL;DR: In this article, the authors proposed a method for targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans).