Maxwell H. Anderson

TL;DR: This review describes some of the interesting interspecies-interaction scenarios in oral microbial communities, which indicate that the whole is much more than the simple sum of its parts, since the interactions between different parts resulted in many new physiological functions which cannot be observed with individual components.

TL;DR: It is reported for the first time that luxS-dependent quorum sensing is involved in biofilm formation of Streptococcus mutans, a major cariogenic bacterium in the multispecies bacterial biofilm commonly known as dental plaque.

TL;DR: The STAMPs presented here are capable of eliminating S. mutans from multispecies biofilms without affecting closely related noncariogenic oral streptococci, indicating the potential of these molecules to be developed into “probiotic” antibiotics which could selectively eliminate pathogens while preserving the protective benefits of a healthy normal flora.

TL;DR: The successful creation of the first synthetic, target-specific antimicrobial peptide, G10KHc, is reported, via addition of a rationally designed Pseudomonas-specific targeting moiety (KH) to a generally killing peptide (novispirin G10).

TL;DR: In this paper, in various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species, and the chimeric peptide is used to provide novel targeted antimicrobial compositions.