Study of the interaction of an anticancer drug with human and bovine serum albumin: Spectroscopic approach

Interactions of human serum albumin with chlorogenic acid and ferulic acid.

Binding analysis of glycyrrhetinic acid to human serum albumin: fluorescence spectroscopy, FTIR, and molecular modeling.

In this paper, the interaction between p-aminoazobenzene (PAAB) and BSA was investigated mainly by fluorescence quenching spectra, circular dichroism (CD) and three-dimensional fluorescence spectra under simulative physiological conditions. It was proved that the fluorescence quenching of BSA by PAAB was mainly a result of the formation of a PAAB-BSA complex. The modified Stern-Volmer quenching constant Ka and the corresponding thermodynamic parameters ΔH, ΔG and ΔS at different temperatures were calculated. The results indicated that van der Waals interactions and hydrogen bonds were the predominant intermolecular forces in stabilizing the complex. The distance r = 4.33 nm between the donor (BSA) and acceptor (PAAB) was obtained according to Forster’s non-radioactive energy transfer theory. The synchronous fluorescence, CD and three-dimensional fluorescence spectral results showed that the hydrophobicity of amino acid residues increased and the losing of α-helix content (from 63.57 to 51.83%) in the presence of PAAB. These revealed that the microenvironment and conformation of BSA were changed in the binding reaction.

Fluorescence Study on the Interaction of Bovine Serum Albumin with P-Aminoazobenzene

Study of the interaction between icariin and human serum albumin by fluorescence spectroscopy

Interactions between 1-benzoyl-4-p-chlorophenyl thiosemicarbazide and serum albumin: investigation by fluorescence spectroscopy

Interaction of human serum albumin with N-(4-ethoxyphenyl)-N'-(4-antipyrinyl) thiourea using spectroscopies and molecular modeling method

In this paper, the Zn/NH 4 Cl/C 2 H 5 OH/H 2 O system was applied for the selective 1,4-reduction of chalcones under mild conditions with high selectivity. The merit lies in inexpensive reagent, simple operation and environmental friendliness. The structures of the products were characterized by IR, 1 H NMR, MS spectra and elemental analysis. A possible mechanism is also suggested.

Selective 1,4‐Reduction of Chalcones with Zn/NH4Cl/C2H5OH/H2O

The binding of 3-(p-bromophenyl)-5-methyl-thiohydantoin with human serum albumin: Investigation by fluorescence spectroscopy and molecular model

Thiourea is an inexpensive, efficient and mild catalyst for the synthesis of Knoevenagel condensation of pyrozoles derivate. In the presence of 10 mol% of thiourea, pyrazole aldehyde react with active methylene compound under microwave-assisted solvent-free conditions at 300 W for 2-5 min to give corresponding products in good yields.

http://proj3.sinica.edu.tw/~chem/servxx6/files/paper_13682_1302150701.pdf

Jian-Ping Li

Papers

Interactions between 1-benzoyl-4-p-chlorophenyl thiosemicarbazide and serum albumin: investigation by fluorescence spectroscopy

Interaction of human serum albumin with N-(4-ethoxyphenyl)-N'-(4-antipyrinyl) thiourea using spectroscopies and molecular modeling method

Selective 1,4‐Reduction of Chalcones with Zn/NH4Cl/C2H5OH/H2O

The binding of 3-(p-bromophenyl)-5-methyl-thiohydantoin with human serum albumin: Investigation by fluorescence spectroscopy and molecular model

Thiourea: An Efficient and Inexpensive Catalyst for the Knoevenagel Condensation of Pyrazole Derivates