J
Jian Zhu
Researcher at United States Military Academy
Publications - 6
Citations - 1491
Jian Zhu is an academic researcher from United States Military Academy. The author has contributed to research in topics: Apoptosis & Cancer research. The author has an hindex of 4, co-authored 4 publications receiving 1458 citations.
Papers
More filters
Journal Article
Epothilones, a New Class of Microtubule-stabilizing Agents with a Taxol-like Mechanism of Action
Daniel M. Bollag,Patricia A. McQueney,Jian Zhu,Otto D. Hensens,Lawrence R. Koupal,Jerrold M. Liesch,Michael A. Goetz,Elias Lazarides,Catherine M. Woods +8 more
TL;DR: Epothilones represent a novel structural class of compounds, the first to be described since the original discovery ofTaxol, which not only mimic the biological effects of taxol but also appear to bind to the same microtubule-binding site as taxol.
Journal ArticleDOI
Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway.
TL;DR: Taxol induces two forms of cell cycle arrest, which in turn induce two independent apoptotic pathways, whereas G1-block and the resulting slow (3–5 days) apoptotic pathway are p53 dependent.
Journal ArticleDOI
Identification of a novel Ca(2+)-regulated protein that is associated with the marginal band and centrosomes of chicken erythrocytes
TL;DR: It is hypothesized that the mechanism of p23 association to the MB and centrosomes may be induced in part by a decrease in intracellular [Ca2+] during the terminal stages of definitive erythropoiesis.
Journal ArticleDOI
Novel centrosomal protein reveals the presence of multiple centrosomes in turkey ( Meleagris gallopavo) bnbn binucleated erythrocytes
TL;DR: Two variants of the novel, centrosomally-associated erythroid-specific protein p23 are identified in turkey, one of which is Ca(2+)-sensitive and is highly homologous to its chick counterpart, and the other, p21 is a truncated form resulting from a 62 amino acid deletion from the 3' end and a 40 amino acid insertion at the 5' end.
Journal ArticleDOI
Hsa_circ_0097922 promotes tamoxifen resistance and cell malignant behaviour of breast cancer cells by regulating ACTN4 expression via miR‐876‐3p
TL;DR: Hsa_circ_0097922 might regulate BC cell malignant behavior and tamoxifen resistance partly by regulating the miR-876-3p/ACTN4 axis, hinting at a promising therapeutic target for the BC treatment.