J
Jianfei Chen
Researcher at Third Military Medical University
Publications - 28
Citations - 704
Jianfei Chen is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Progenitor cell & RAGE (receptor). The author has an hindex of 14, co-authored 28 publications receiving 633 citations.
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Advanced glycation endproducts alter functions and promote apoptosis in endothelial progenitor cells through receptor for advanced glycation endproducts mediate overpression of cell oxidant stress
TL;DR: AGEs may serve to impair E PCs functions through RAGE-mediate oxidant stress, and promote EPCs sensitivity toward oxidative-stress-mediated apoptosis, which indicates a new pathophysiological mechanism of disturbed vascular adaptation in atherosclerosis and suggests that lower levels of AGEs might improve the success of progenitor cell therapy.
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An essential role for stromal interaction molecule 1 in neointima formation following arterial injury
Rui-wei Guo,Hong Wang,Pan Gao,Mao-Quan Li,Chunyu Zeng,Yang Yu,Jianfei Chen,Mingbao Song,Yan-kun Shi,Lan Huang +9 more
TL;DR: Results suggest STIM1 has a critical role in neointimal formation in a rat model of vascular injury and may represent a novel therapeutic target in the prevention of restenosis after vascular interventions.
Journal Article
Advanced glycation endproducts induce apoptosis of endothelial progenitor cells by activating receptor RAGE and NADPH oxidase/JNK signaling axis
TL;DR: The findings suggest that dysregulation of the AGEs/RAGE axis in EPCs may promote atherosclerosis and identify the NADPH/ROS/JNK signaling axis as a potential target for therapeutic intervention.
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Blockade of connexin 43 hemichannels reduces neointima formation after vascular injury by inhibiting proliferation and phenotypic modulation of smooth muscle cells.
TL;DR: In this article, the effect of intercellular communication mediated by Cx43 hemichannels on neointimal formation after vascular injury was investigated, and it was shown that the gap junction-dependent function of cx43 has a crucial role in the development and progression of vascular diseases.
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Transfection of HGF gene enhances endothelial progenitor cell (EPC) function and improves EPC transplant efficiency for balloon-induced arterial injury in hypercholesterolemic rats
TL;DR: The data suggest that gene delivery combined with EPC transplant may be a practical and promising therapy for the prevention of neointimal formation after vascular injury.