Jiangmei Wu

TL;DR: This work has suggested that blue light may play a role in the pathogenesis of age-related macular degeneration, and laboratory studies have suggested that photochemical damage includes oxidative events.

TL;DR: Photoreceptor cell apoptosis is seen early after the retina is damaged by blue light, as demonstrated by in situ terminal dUTP nick end labelling (TUNEL) and gel electrophoresis in rats reared under cyclic light.

TL;DR: Investigating the effect of PPP on VEGF expression, both in vitro and in vivo, and whether this effect has antiangiogenic consequences in a murine CNV model concluded that IGF-1R inhibitors may be useful tools in the treatment of conditions associated with CNV.

TL;DR: Choroidal neovascularization is a debilitating complication of age‐related macular degeneration and a leading cause of vision loss and angiogenic factors like vascular endothelial growth factor, insulin‐like growth factor and its receptor, IGF‐1R, have been implicated in CNV.

TL;DR: The study demonstrated that the ear thickness, redness, swelling, and neutrophil infiltration were significantly increased, accompanied by increased expression of inflammatory cytokines and decreased expression of antioxidant genes (HO-1 and NQO1) in Nrf2 knockout mice.