J
Jianguo Chen
Researcher at Jiangsu University
Publications - 35
Citations - 1226
Jianguo Chen is an academic researcher from Jiangsu University. The author has contributed to research in topics: Peripheral blood mononuclear cell & Antibody. The author has an hindex of 15, co-authored 33 publications receiving 1067 citations.
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Journal ArticleDOI
Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis.
Jie Ma,Chenlu Zhu,Bin Ma,Jie Tian,Samuel Essien Baidoo,Chaoming Mao,Wei Wu,Jianguo Chen,Jia Tong,Min Yang,Zhijun Jiao,Huaxi Xu,Liwei Lu,Shengjun Wang +13 more
TL;DR: It is shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of T fh cells in the disease progression of RA.
Journal ArticleDOI
Increased Frequency of Follicular Helper T Cells in Patients with Autoimmune Thyroid Disease
Chenlu Zhu,Jie Ma,Yingzhao Liu,Jia Tong,Jie Tian,Jianguo Chen,Xinyi Tang,Huaxi Xu,Liwei Lu,Shengjun Wang +9 more
TL;DR: An increased frequency of Tfh cells is discovered in patients with autoimmune thyroid disease, which implies that this cell subset might play an important role in the pathogenesis of AITD.
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Decreased expression of microRNA‐21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis
Liyang Dong,Xuefeng Wang,Jun Tan,Hao Li,Qian Wei,Jianguo Chen,Qiaoyun Chen,Jun Wang,Wenlin Xu,Cai-hua Tao,Shengjun Wang +10 more
TL;DR: MiR‐21 may serve as a novel regulator in T‐cell differentiation and homoeostasis, and provides a new therapeutic target for the treatment of RA.
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Differentiation imbalance of Th1/Th17 in peripheral blood mononuclear cells might contribute to pathogenesis of Hashimoto's thyroiditis.
Yan Shi,H. Wang,Zhicheng Su,Jianguo Chen,Y. Xue,Shengjun Wang,Zhubing He,Heng Yang,C. Zhou,Fanzhi Kong,Yingzhao Liu,Peidong Yang,Liwei Lu,Qing Shao,Xinxiang Huang,Huaxi Xu +15 more
TL;DR: This study investigated the expression levels of Th1/Th17 cell‐associated factors in peripheral blood mononuclear cells (PBMC) and plasma from patients with HT by quantitative real‐time polymerase chain reaction (RT‐qPCR) and enzyme‐linked immunosorbent assay (ELISA), suggesting that Th17 cells rather than Th1 cells predominated among patients suffering from HT.
Journal ArticleDOI
Identification and characterization of class 1 integrons among Pseudomonas aeruginosa isolates from patients in Zhenjiang, China
Jianguo Chen,Zhaoliang Su,Yingzhao Liu,Shengjun Wang,Xiaoli Dai,Yazhen Li,Sufang Peng,Qixiang Shao,Haifang Zhang,Ping Wen,Jianren Yu,Xinxiang Huang,Huaxi Xu +12 more
TL;DR: Class 1 integrons were found to be widespread in P. aeruginosa isolated from clinical samples in the Zhenjiang area of China and PFGE showed that particular clones were circulating among patients.