Jianhua Cao

TL;DR: Examination of extracellular ligand binding to the venus flytrap domains of the dimeric metabotropic glutamate receptors shows that a specific association of the two CRDs corresponds to the active state of the receptor, and demonstrates that intersubunit movement at the level of the CRDs represents a key step in metabotrop glutamate receptor activation.

TL;DR: A trimodular activity-based probe was designed, synthesized, characterized, and applied to photoaffinity label the GABA(B) receptors transiently expressed in Chinese hamster ovary (CHO) cells, which makes the probe valuable for studying the localization and function of GABA( B) receptors on living cells.

TL;DR: The results show that functional divergence involved positive selection and is partially responsible for the evolutionary patterns of the class C GPCR VFTMs.

TL;DR: This study uniquely elucidates the association mechanism of Lp-PLA2 with membranes and its resulting conformational change as well as the extraction and binding of specific oxidized and short acyl-chain phospholipid substrates not previously possible.

TL;DR: In this article , three fluorescent sensors of Nap-OH, Nap-C and Nap-NO2 based on twisted intramolecular charge transfer (TICT) are designed and synthesized for detecting of human serum albumin (HSA), and the effect of electron donating-withdrawing groups of sensors on the detection of HSA is studied.