Jianling Li

TL;DR: QSAR study revealed that the presence of electron-withdrawing groups in B-ring and electron-donating groups in A-ring of chalcones was important for inhibition of LPS-induced IL-6 expression, and showed a series of anti-inflammatory chalcone derivatives with potential therapeutic effects in inflammatory diseases.

TL;DR: It is hypothesized that C66 affects high glucose (HG)‐induced inflammation profiles in vitro and in vivo and then prevents renal injury in diabetic rats via its anti‐inflammatory actions.

TL;DR: Quantitative structure-activity relationship was conducted, indicating that electron-withdrawing groups in benzene ring are favourable to anti-inflammatory activities of B-class compounds, and compounds AN1 and B82 demonstrated anti- inflammatory abilities in a dose-dependent manner, raising the possibility that these compounds might serve as potential agents for the treatment of inflammatory diseases.

TL;DR: C12 suppressed proinflammatory cytokine production in plasma and liver, attenuated lung histopathology, and significantly reduced mortality in endotoxemic mice, suggesting that this agent may be useful in the treatment of inflammatory diseases.

TL;DR: In this paper , the role of phytosterols was verified in LPS-stimulated RAW264.7 cells and the protective effect was weakened by administration of LXR antagonist GSK2033.