J
Jianzhong Wang
Researcher at Chinese PLA General Hospital
Publications - 25
Citations - 808
Jianzhong Wang is an academic researcher from Chinese PLA General Hospital. The author has contributed to research in topics: Angiotensin II & Senescence. The author has an hindex of 16, co-authored 25 publications receiving 733 citations. Previous affiliations of Jianzhong Wang include Chinese General Hospital College of Nursing and Liberal Arts.
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MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9
Jurong Yang,Dapeng Chen,Dapeng Chen,Ya-ni He,Alicia Meléndez,Zhe Feng,Quan Hong,Xueyuan Bai,Qinggang Li,Guangyan Cai,Jianzhong Wang,Xiangmei Chen +11 more
TL;DR: It is reported that a mir-34 loss-of-function mutation in Caenorhabditis elegans markedly delays the age-related physiological decline, extends lifespan, and increases resistance to heat and oxidative stress, and that miR-34 represses autophagy by directly inhibiting the expression of the autophagic-related proteins Atg9 in mammalian cells.
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Downregulation of Connexin 43 Expression by High Glucose Induces Senescence in Glomerular Mesangial Cells
Xiaojie Zhang,Xiangmei Chen,Di Wu,Weiping Liu,Jianzhong Wang,Zhe Feng,Guangyan Cai,Bo Fu,Quan Hong,Jing Du +9 more
TL;DR: It is demonstrated for the first time that downregulation of Cx43 expression by high glucose promotes the senescence of GMC, which may be involved in the pathogenesis of diabetic nephropathy.
Journal ArticleDOI
SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3–FOXO1 signaling pathway
Bin Zhang,Bin Zhang,Bin Zhang,Shaoyuan Cui,Xueyuan Bai,Li Zhuo,Xuefeng Sun,Quan Hong,Bo Fu,Jianzhong Wang,Xiangmei Chen,Xiangmei Chen,Guangyan Cai +12 more
TL;DR: It is demonstrated for the first time that Sirtuin 3 overexpression antagonizes high glucose-induced cellular senescence in human diploid fibroblasts via the SIRT3–FOXO1 signaling pathway.
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Mitochondrial Pathway Is Responsible for Aging-Related Increase of Tubular Cell Apoptosis in Renal Ischemia/Reperfusion Injury
Xi Qiao,Xiangmei Chen,Di Wu,Rui Ding,Jianzhong Wang,Quan Hong,Suozhu Shi,Jianjun Li,Yuansheng Xie,Yang Lu,Zhaoxia Wang +10 more
TL;DR: It is demonstrated that there was an aging-related increase of tubular cell apoptosis in the renal I/R model, which may be, at least partly, due to an enhanced mitochondrial pathway resulting possibly from increased oxidative stress.
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TIMP-1 Promotes Age-Related Renal Fibrosis Through Upregulating ICAM-1 in Human TIMP-1 Transgenic Mice
Xueguang Zhang,Xiangmei Chen,Quan Hong,Hongli Lin,Hanyu Zhu,Qingxin Liu,Jianzhong Wang,Yuansheng Xie,Xiyao Shang,Suozhu Shi,Yang Lu,Zhong Yin +11 more
TL;DR: The results indicated that TIMP-1 could promote age-related renal fibrosis, which was partly attributed to enhancing inflammation through upregulation of ICAM-1.