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Xiangmei Chen
Researcher at Chinese PLA General Hospital
Publications - 397
Citations - 7430
Xiangmei Chen is an academic researcher from Chinese PLA General Hospital. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 36, co-authored 367 publications receiving 5422 citations. Previous affiliations of Xiangmei Chen include Fourth Military Medical University & Guangdong Pharmaceutical University.
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miR-335 and miR-34a Promote Renal Senescence by Suppressing Mitochondrial Antioxidative Enzymes
TL;DR: It is suggested that miRNAs may contribute to renal aging by inhibiting intracellular pathways such as those involving the mitochondrial antioxidative enzymes SOD2 and Txnrd2.
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Mesenchymal stem cells ameliorate rhabdomyolysis-induced acute kidney injury via the activation of M2 macrophages
Yan-qiu Geng,Li Zhang,Bo Fu,Jianrong Zhang,Quan Hong,Jie Hu,Diangeng Li,Congjuan Luo,Shaoyuan Cui,Fei Zhu,Xiangmei Chen +10 more
TL;DR: It is suggested that MSCs can ameliorate rhabdomyolysis-induced AKI via the activation of macrophages to a trophic M2 phenotype, which supports the transition from tubule injury to tubule repair.
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LncRNA HOTAIR regulates HIF-1α/AXL signaling through inhibition of miR-217 in renal cell carcinoma.
Quan Hong,Ou Li,Wei Zheng,Wenzhen Xiao,Lu Zhang,Di Wu,Guangyan Cai,John Cijiang He,Xiangmei Chen +8 more
TL;DR: It is suggested that HOTAIR promotes Rcc tumorigenesis via miR-217/HIF-1α/AXL signaling, which may provide a new target for the diagnosis and therapy of Rcc disease.
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Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling
Jun Liu,Kun Huang,Guangyan Cai,Xiangmei Chen,Jurong Yang,Lirong Lin,Jie Yang,Bengang Huo,Jun Zhan,Yani He +9 more
TL;DR: It is demonstrated that elevated expression of RAGE, ER stress marker glucose-regulated protein 78 (GRP78), and cell-cycle regulator p21 was all positively correlated with enhanced senescence-associated- β-galactosidase (SA-β-gal) activity in DN patients.
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Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury
Quan Hong,Quan Hong,Lu Zhang,Lu Zhang,Bhaskar C. Das,Zhengzhe Li,Bohan Liu,Guangyan Cai,Xiangmei Chen,Peter Y. Chuang,John Cijiang He,Kyung Lee +11 more
TL;DR: Increased SIRT1 activity protects against diabetes-induced podocyte injury and effectively mitigates the progression of diabetic kidney disease.