J
Jiayun Chen
Researcher at Rockefeller University
Publications - 8
Citations - 6167
Jiayun Chen is an academic researcher from Rockefeller University. The author has contributed to research in topics: Gating & KcsA potassium channel. The author has an hindex of 8, co-authored 8 publications receiving 5998 citations. Previous affiliations of Jiayun Chen include Howard Hughes Medical Institute.
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Journal ArticleDOI
X-ray structure of a voltage-dependent K+ channel
Youxing Jiang,Alice Lee,Jiayun Chen,Vanessa Ruta,Martine Cadene,Brian T. Chait,Roderick MacKinnon +6 more
TL;DR: The structure of KvAP, a voltage-dependent K+ channel from Aeropyrum pernix, is presented and a crystal structure of the full-length channel at a resolution of 3.2 Å is determined, which suggests that the voltage-sensor paddles move in response to membrane voltage changes, carrying their positive charge across the membrane.
Journal ArticleDOI
Crystal structure and mechanism of a calcium-gated potassium channel
TL;DR: This work has cloned, expressed, analysed electrical properties, and determined the crystal structure of a K+ channel (MthK) from Methanobacterium thermoautotrophicum in the Ca2+-bound, opened state.
Journal ArticleDOI
The open pore conformation of potassium channels.
TL;DR: Amino-acid sequence conservation suggests a common structural basis for gating in a wide range of K+ channels, both ligand- and voltage-gated.
Journal ArticleDOI
The principle of gating charge movement in a voltage-dependent K + channel
TL;DR: It is concluded that the voltage-sensor paddles operate somewhat like hydrophobic cations attached to levers, enabling the membrane electric field to open and close the pore.
Journal ArticleDOI
Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution
TL;DR: The combination of observations of conductive and inhibitory ion binding sites with electrophysiological data finally explains the mechanism of action of these long-studied channels and reveals how they maintain their low sensitivity to toxins, as well as provides a basis for the design of therapeutic drugs.