Ten years of hemovigilance reports of transfusion-related acute lung injury in the United Kingdom and the impact of preferential use of male donor plasma

Neutrophil Fc gamma RIIIb deficiency, nature, and clinical consequences: a study of 21 individuals from 14 families.

Characterization of a New Alloantigen (SH) on the Human Neutrophil Fcγreceptor IIIb

Objective This review describes alloantigens currently listed in the human neutrophil alloantigen (HNA) system.



Material and Methods  Review of the literature.



Results  Neutrophil antigens are implicated in a variety of clinical conditions including neonatal immune neutropenia, transfusion-related acute lung injury, refractoriness to granulocyte transfusions, febrile transfusion reactions, immune neutropenia after bone marrow transplantation, autoimmune neutropenia and drug-induced immune neutropenia. Seven antigens have been listed in the HNA system that are assigned to five antigen groups. Six antigens have been characterized biochemically and molecularly so that their primary structure is now known. As shown by regularly performed international granulocyte immunology workshops, a combination of granulocyte agglutination and immunofluorescence tests together with a panel of typed cells is currently the best means of detection.



Conclusions  Most of the HNA antigens have been well-characterized so that HNA typing as well as the detection of the corresponding antibodies are now reliably possible. This will improve diagnostics of neutrophil antibody-mediated clinical conditions as well as the prevention of transfusion-related acute lung injury.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1423-0410.2007.01031.x

Jiirgen Bux

Papers

NA gene frequencies in the German population, determined by polymerase chain reaction with sequence-specific primers.