J
Jill Sollenberger
Researcher at University of Nottingham
Publications - 1
Citations - 115
Jill Sollenberger is an academic researcher from University of Nottingham. The author has contributed to research in topics: Autophagy & Sequestosome-1 Protein. The author has an hindex of 1, co-authored 1 publications receiving 89 citations.
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Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.
Alice Goode,Kevin Butler,Jed Long,James R. Cavey,Daniel Scott,Barry Shaw,Jill Sollenberger,Christopher Gell,Terje Johansen,Neil J. Oldham,Mark S. Searle,Robert Layfield +11 more
TL;DR: It is shown that although representing a conservative substitution and predicted to be benign, the ALS-associated L341V mutation of SQSTM1 is defective in recognition of LC3B, a key protein-protein interaction in autophagy which could expose a vulnerability over the lifetime of a neuron, which ultimately tips the balance from cell survival toward cell death.