Cancer nanotherapeutics are rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability, and low therapeutic indices. To improve the biodistribution of cancer drugs, nanoparticles have been designed for optimal size and surface characteristics to increase their circulation time in the bloodstream. They are also able to carry their loaded active drugs to cancer cells by selectively using the unique pathophysiology of tumors, such as their enhanced permeability and retention effect and the tumor microenvironment. In addition to this passive targeting mechanism, active targeting strategies using ligands or antibodies directed against selected tumor targets amplify the specificity of these therapeutic nanoparticles. Drug resistance, another obstacle that impedes the efficacy of both molecularly targeted and conventional chemotherapeutic agents, might also be overcome, or at least reduced, using nanoparticles. Nanoparticles have the ability to accumulate in cells without being recognized by P-glycoprotein, one of the main mediators of multidrug resistance, resulting in the increased intracellular concentration of drugs. Multifunctional and multiplex nanoparticles are now being actively investigated and are on the horizon as the next generation of nanoparticles, facilitating personalized and tailored cancer treatment.

https://clincancerres.aacrjournals.org/content/clincanres/14/5/1310.full.pdf

Therapeutic Nanoparticles for Drug Delivery in Cancer

Magnetic Nanoparticles in MR Imaging and Drug Delivery

This article reviews the requirements for successful compressed sensing (CS), describes their natural fit to MRI, and gives examples of four interesting applications of CS in MRI. The authors emphasize on an intuitive understanding of CS by describing the CS reconstruction as a process of interference cancellation. There is also an emphasis on the understanding of the driving factors in applications, including limitations imposed by MRI hardware, by the characteristics of different types of images, and by clinical concerns.

/pdf/compressed-sensing-mri-2wgw41cvre.pdf

Compressed Sensing MRI

Optogenetics in neural systems.

The present disclosure provides a device for carrying out magnetic resonance imaging compatible optogenetics; and methods for using the device.

Jin Hyung Lee

Papers

Carbon fiber optrodes for magnetic resonance imaging compatible optogenetics