J
Jin Zhang
Researcher at Genzyme
Publications - 2
Citations - 112
Jin Zhang is an academic researcher from Genzyme. The author has contributed to research in topics: Chinese hamster ovary cell & Upstream open reading frame. The author has an hindex of 2, co-authored 2 publications receiving 107 citations.
Papers
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Journal ArticleDOI
Accelerated Clone Selection for Recombinant CHO Cells Using a FACS-Based High-Throughput Screen
Christine Demaria,Victor R. Cairns,Cordula Schwarz,Jin Zhang,Megan Guerin,Erin Zuena,Scott Estes,Kenneth P. Karey +7 more
TL;DR: This method provides an effective process for generating recombinant cell lines producing high levels of therapeutic proteins, with the benefits of rapid and accurate 96‐well plate clone screening and elimination of unstable clones at an earlier stage in the development process.
Journal ArticleDOI
Utilization of non-AUG initiation codons in a flow cytometric method for efficient selection of recombinant cell lines.
Victor R. Cairns,Christine Demaria,Francis Poulin,Jose Sancho,Ping Liu,Jin Zhang,Juanita Campos-Rivera,Kenneth P. Karey,Scott Estes +8 more
TL;DR: A method that couples flow cytometric detection with the attenuated translation of a reporter protein to enable efficient selection of CHO clones producing high levels of recombinant proteins to enable resources to be focused solely on clones with both high and stable expression is described.