S
Scott Estes
Researcher at Biogen Idec
Publications - 26
Citations - 1281
Scott Estes is an academic researcher from Biogen Idec. The author has contributed to research in topics: Chinese hamster ovary cell & Promoter. The author has an hindex of 13, co-authored 24 publications receiving 1128 citations. Previous affiliations of Scott Estes include Genzyme.
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Journal ArticleDOI
Human cell lines for biopharmaceutical manufacturing: history, status, and future perspectives
TL;DR: With additional research investment, human cell lines may be further optimized for routine commercial production of a broader range of biotherapeutic proteins.
Journal ArticleDOI
Tumors Associated With Oncogenic Osteomalacia Express Genes Important in Bone and Mineral Metabolism
Suzanne M. Jan de Beur,Richard Finnegan,John Vassiliadis,Brian P. Cook,Dana Barberio,Scott Estes,Partha Manavalan,Joseph M. Petroziello,Stephen L. Madden,Justin Cho,Rajiv Kumar,Michael A. Levine,Susan C. Schiavi +12 more
TL;DR: Gene expression profiles of tumors resected from patients with OOM and histologically similar control tumors were compared and genes with roles in bone matrix formation, mineral ion transport, and bone mineralization were highly expressed in the OOM tumors.
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Development of a simple and rapid method for producing non‐fucosylated oligomannose containing antibodies with increased effector function
Qun Zhou,Srinivas Shankara,Andre Roy,Huawei Qiu,Scott Estes,Alison McVie-Wylie,Kerry Culm-Merdek,Anna Park,Clark Pan,Tim Edmunds +9 more
TL;DR: The use of kifunensine provides a simple and rapid method for the production of antibodies with increased ADCC without the time‐consuming need to re‐engineer either the antibody molecule or the host cell line.
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Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine.
Huawei Qiu,Tim Edmunds,Jennifer Baker-Malcolm,Kenneth P. Karey,Scott Estes,Cordula Schwarz,Heather Hughes,Scott M. Van Patten +7 more
TL;DR: Results indicate that purified rhASM can be activated in vitro by loss of the free thiol on the C-terminal cysteine via chemical modification, dimerization, or deletion of this amino acid residue.
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Accelerated Clone Selection for Recombinant CHO Cells Using a FACS-Based High-Throughput Screen
Christine Demaria,Victor R. Cairns,Cordula Schwarz,Jin Zhang,Megan Guerin,Erin Zuena,Scott Estes,Kenneth P. Karey +7 more
TL;DR: This method provides an effective process for generating recombinant cell lines producing high levels of therapeutic proteins, with the benefits of rapid and accurate 96‐well plate clone screening and elimination of unstable clones at an earlier stage in the development process.