J
Jing Ling
Researcher at Zhejiang University
Publications - 5
Citations - 62
Jing Ling is an academic researcher from Zhejiang University. The author has contributed to research in topics: Deubiquitinating enzyme & Gene knockdown. The author has an hindex of 2, co-authored 4 publications receiving 21 citations.
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Journal ArticleDOI
USP14 promotes K63‐linked RIG‐I deubiquitination and suppresses antiviral immune responses
Hongrui Li,Zizhao Zhao,Jing Ling,Linhui Pan,Xibao Zhao,Xibao Zhao,Huihui Zhu,Juan Yu,Bin Xie,Jianzhong Shen,Weilin Chen,Weilin Chen +11 more
TL;DR: USP14 knockdown significantly enhanced RIG‐I‐triggered type I IFN signaling and inhibited vesicular stomatitis virus (VSV) replication both in mouse peritoneal macrophages and THP1 cells.
Journal ArticleDOI
P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6
Xibao Zhao,Xibao Zhao,Fei-Yang Ji,Hongrui Li,Hongrui Li,Huihui Zhu,Zizhao Zhao,Jing Ling,Qianqian Di,Xingyu Ma,Weilin Chen +10 more
TL;DR: It is demonstrated that P22077 could attenuate the release of pro-inflammatory factors, suppress mRNA expression of COX-2 and iNOS, and inhibit activation of NF-κB and MAPKs signaling pathways in Raw264.7 cells and mouse peritoneal macrophages after LPS stimulation.
Journal ArticleDOI
USP14 negatively regulates RIG-I-mediated IL-6 and TNF-α production by inhibiting NF-κB activation.
TL;DR: In this paper, the effect of USP14 on RNA virus-related inflammatory response has been studied and it was shown that USP 14-overexpressed HeLa cells exhibited a decrease in RIG-I-mediated IL-6 and TNF-α expression.
Journal ArticleDOI
MEF2C promotes M1 macrophage polarization and Th1 responses
Xibao Zhao,Qianqian Di,Han Liu,Jiazheng Quan,Jing Ling,Zizhao Zhao,Yue Xiao,Han Wu,Zherui Wu,Wengang Song,Huazhang An,Weilin Chen +11 more
TL;DR: In this article , the authors showed that myocyte enhancer factor 2 C (MEF2C) is essential for regulating M1 macrophage polarization in response to infection and inflammation.
Journal ArticleDOI
Protein ubiquitination on the regulation of inflammatory bowel disease
TL;DR: The role and regulatory mechanism of RNF183, RNF20, Itch and A20 in the pathogenesis of inflammatory bowel disease is reviewed.