Journal•ISSN: 0161-5890
Molecular Immunology
Elsevier BV
About: Molecular Immunology is an academic journal published by Elsevier BV. The journal publishes majorly in the area(s): Antibody & Antigen. It has an ISSN identifier of 0161-5890. Over the lifetime, 9980 publications have been published receiving 288517 citations.
Topics: Antibody, Antigen, Immune system, Epitope, Monoclonal antibody
Papers published on a yearly basis
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TL;DR: The effector arm of innate immunity has been tackled, largely though the use of biochemical methods, and genetic dissection of innate immune pathways has been pursued with great success in model organisms.
1,189 citations
TL;DR: The structures of the various regions of an antibody molecule are analysed and correlated with biological function and potential applications are detailed.
993 citations
TL;DR: The weight of the evidence is that CRP like other acute-phase proteins is a component first line of innate host defense and appears to be host defense against bacterial pathogens and clearance of apoptotic and necrotic cells.
841 citations
TL;DR: It is demonstrated that the region (−323 to −285) encompassing −308 in the TNF2 allele binds nuclear factors differently to the same region in the promoter of the more common TNF1 allele, suggesting that the −308 GA polymorphism may play a role in the altered TNF-α gene expression observed in individuals with the HLA Al, B8, DR3 haplotype.
836 citations
TL;DR: A novel function of IL-6 is discussed: the control of T helper (Th) 1/Th2 differentiation, which plays a dual role in Th1/Th1 differentiation by using two independent molecular mechanisms.
795 citations