J
Jing Yan
Researcher at China Medical University (PRC)
Publications - 2
Citations - 26
Jing Yan is an academic researcher from China Medical University (PRC). The author has contributed to research in topics: Oligonucleotide & Locked nucleic acid. The author has an hindex of 2, co-authored 2 publications receiving 26 citations.
Papers
More filters
Journal ArticleDOI
Effect of LNA- and OMeN-modified oligonucleotide probes on the stability and discrimination of mismatched base pairs of duplexes
TL;DR: Five LNA- and five OMeN-modified oligonucleotide probes were designed to simulate realistic situations where target–probe duplexes contain a complementary LNA:DNA or O meN:DNA base pairs and a DNA:DNA mismatch simultaneously.
Journal ArticleDOI
Enhanced recognition of non-complementary hybridization by single-LNA-modified oligonucleotide probes
TL;DR: It was observed that LNA modification indeed improves the discrimination capability of oligonucleotides by increasing the melting temperature differences between the complementary duplexes and hybrids containing mismatches.