J
Jinglin Yang
Researcher at Tsinghua University
Publications - 3
Citations - 554
Jinglin Yang is an academic researcher from Tsinghua University. The author has contributed to research in topics: Heterogeneous network & Drug development. The author has an hindex of 3, co-authored 3 publications receiving 340 citations.
Papers
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Journal ArticleDOI
A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information
Yunan Luo,Xinbin Zhao,Jingtian Zhou,Jinglin Yang,Yanqing Zhang,Wenhua Kuang,Jian Peng,Ligong Chen,Ligong Chen,Jianyang Zeng +9 more
TL;DR: DTINet is introduced, whose performance is enhanced in the face of noisy, incomplete and high-dimensional biological data by learning low-dimensional vector representations, which accurately explains the topological properties of individual nodes in the heterogeneous network.
Proceedings Article
A Network Integration Approach for Drug-Target Interaction Prediction and Computational Drug Repositioning from Heterogeneous Information.
Yunan Luo,Yunan Luo,Xinbin Zhao,Jingtian Zhou,Jinglin Yang,Yanqing Zhang,Wenhua Kuang,Jian Peng,Ligong Chen,Jianyang Zeng +9 more
TL;DR: DTINet as mentioned in this paper predicts novel drug-target interactions from a constructed heterogeneous network, which integrates diverse drug-related information by learning a low-dimensional vector representation of features, and then makes prediction based on these representations via a vector space projection scheme.
Posted ContentDOI
A Network Integration Approach for Drug-Target Interaction Prediction and Computational Drug Repositioning from Heterogeneous Information
Yunan Luo,Xinbin Zhao,Jingtian Zhou,Jinglin Yang,Yanqing Zhang,Wenhua Kuang,Jian Peng,Ligong Chen,Jianyang Zeng +8 more
TL;DR: The novel interactions between three drugs and the cyclooxygenase (COX) protein family are experimentally validated, and the new potential applications of these identified COX inhibitors are demonstrated in preventing inflammatory diseases.