Swellable hollow periodic mesoporous organosilica capsules with ultrahigh loading capacity for hydrophobic drugs.

Abstract Hollow capsules with multi-shelled or multicomponent structures are essential materials for various applications. Biomedical applications like disease diagnosis, therapy, and monitoring have special significance as they aim to improve health conditions. This review demonstrated a comprehensive overview of hollow, multifunctional structures incorporating meaningful use of nanotechnology and its’ unique prospects in medicine such as patient-specific treatment, multimodal imaging, multimodal therapy, simultaneous delivery of drugs and imaging probes, and actively targeted delivery. The internal hollow cavity provides safe and controlled drug release while also enabling transport of functional moieties to target sites. This review explored the performance of different organic, inorganic, and metallic multicomponent capsules that have been reported for biomedical applications, mainly diagnostic imaging and drug delivery. Material compositions, morphologies, and synthesis strategies involved in fabricating such multifunctional systems have been discussed in detail. It is expected that with time, more sophisticated and precise systems will come to light as the outcome of ongoing concentrated research efforts. 

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Jinhai Tang

Papers

Hybridized double-shell periodic mesoporous organosilica nanotheranostics for ultrasound imaging guided photothermal therapy.