J
Jinwoong Bok
Researcher at Yonsei University
Publications - 89
Citations - 2177
Jinwoong Bok is an academic researcher from Yonsei University. The author has contributed to research in topics: Inner ear & Cochlea. The author has an hindex of 23, co-authored 82 publications receiving 1834 citations. Previous affiliations of Jinwoong Bok include National Institutes of Health & University of Iowa.
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Multiple distinct signal pathways, including an autocrine neurotrophic mechanism, contribute to the survival-promoting effect of depolarization on spiral ganglion neurons in vitro.
TL;DR: Survition of SGNs under depolarizing conditions involves additivity among a depolarization-independent autocrine pathway, a cAMP-dependent pathway, and a CaMK- dependent pathway.
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Patterning and morphogenesis of the vertebrate inner ear
TL;DR: This review addresses how genes induced within the otic epithelium as a result of axial specification continue to mediate inner ear morphogenesis.
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Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear
TL;DR: The results indicate that SHH, together with other signals from the hindbrain, are important for patterning the ventral axis of the inner ear, and suggest that tissue(s) other than the hind brain confer AP axial information whereas signals fromThe hindbrain are necessary and sufficient for the DV axial patterning of the outer ear.
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Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear.
TL;DR: The study shows that Gli3 repressor (R) is required for patterning dorsal inner ear structures, whereas Gli activator (A) proteins are essential for ventral innerEar structures, and reciprocal gradients of GliA and GliR mediate the responses to Shh signaling along the dorsoventral axis of the inner ear.
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Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells
TL;DR: It is shown that this unique temporal pattern of sensory cell development requires that the adjacent auditory (spiral) ganglion serve as a source of the signaling molecule Sonic hedgehog (Shh) and dictates the timing of terminal mitosis of hair cell precursors and their subsequent differentiation.