Jiri J. Frohlich

TL;DR: Simvastatin plus niacin provides marked clinical and angiographically measurable benefits in patients with coronary disease and low HDL levels, and the use of antioxidant vitamins in this setting must be questioned.

TL;DR: Data provide direct evidence that impairment of cholesterol efflux and consequently reverse cholesterol transport is associated with reduced plasma HDL-C levels and increased risk of CAD.

TL;DR: The causal relation between hypercholesterolemia and atherosclerosis was established more than 80 years ago by Anitschkow as mentioned in this paper, and the results of these early clinical studies and the extensive epidemiological data on the relation between plasma lipoprotein levels and CAD, as well as experimental information from animal models of coronary diseases, led to the development of policies to manage and treat lipid disorders.

TL;DR: Evidence suggests that among wild-type species, strains of White Carneau pigeons and Watanabe Heritable Hyperlipidemic and St. Thomas’s Hospital rabbits are preferable to the cholesterol-fed wild- type animal species in dyslipidemia and atherosclerosis research.