A
Alan Chait
Researcher at University of Washington
Publications - 282
Citations - 57667
Alan Chait is an academic researcher from University of Washington. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 85, co-authored 270 publications receiving 55955 citations. Previous affiliations of Alan Chait include University of Colorado Denver & United States Department of Veterans Affairs.
Papers
More filters
Journal ArticleDOI
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Scott M. Grundy,David W. Bilheimer,Alan Chait,Luther T. Clark,Margo A. Denke,Richard J. Havel,William R. Hazzard,Stephen B. Hulley,Donald B. Hunninghake,Robert A. Kreisberg,Penny M. Kris-Etherton,James M. McKenney,Michael A. Newman,Ernst J. Schaefer,Burton E. Sobel,Carolyn Somelofski,Milton C. Weinstein,H. Bryan Brewer,James I. Cleeman,Karen A. Donato,Nancy D. Ernst,Jeffrey M. Hoeg,Basil M. Rifkind,Jacques E. Rossouw,Christopher T. Sempos,Joanne M. Gallivan,Maureen N. Harris,Laurie Quint-Adler +27 more
TL;DR: Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.
Journal ArticleDOI
Diabetes and cardiovascular disease : A statement for healthcare professionals from the American heart association
Scott M. Grundy,Ivor J. Benjamin,Gregory L. Burke,Alan Chait,Robert H. Eckel,Barbara V. Howard,William E. Mitch,Sidney C. Smith,James R. Sowers +8 more
TL;DR: The most prevalent form of diabetes mellitus is type 2 diabetes as discussed by the authors, which typically makes its appearance later in life and is associated with other cardiovascular risk factors: dyslipidemia, hypertension, and prothrombotic factors.
Journal ArticleDOI
Simvastatin and Niacin, Antioxidant Vitamins, or the Combination for the Prevention of Coronary Disease
B.G. Brown,Xue-Qiao Zhao,Alan Chait,L D Fisher,M.C. Cheung,Josh S. Morse,Alice Dowdy,Emily K Marino,Bolson El,Petar Alaupovic,Jiri J. Frohlich,John J. Albers +11 more
TL;DR: Simvastatin plus niacin provides marked clinical and angiographically measurable benefits in patients with coronary disease and low HDL levels, and the use of antioxidant vitamins in this setting must be questioned.
Journal ArticleDOI
Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL
Tomas Vaisar,Subramaniam Pennathur,Pattie S. Green,Sina A. Gharib,Andrew N. Hoofnagle,Marian C. Cheung,Jaeman Byun,Simona Vuletic,Sean Y. Kassim,Pragya Singh,Helen Chea,Robert H. Knopp,John D. Brunzell,Randolph L. Geary,Alan Chait,Xue Qiao Zhao,Keith B. Elkon,Santica M. Marcovina,Paul M. Ridker,John F. Oram,Jay W. Heinecke +20 more
TL;DR: The observations suggest that HDL plays previously unsuspected roles in regulating the complement system and protecting tissue from proteolysis and that the protein cargo of HDL contributes to its antiinflammatory and antiatherogenic properties.
Journal ArticleDOI
Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis.
Kevin D. O'Brien,Margaret D. Allen,Thomas O. McDonald,Alan Chait,John M. Harlan,Daniel P. Fishbein,John M. McCarty,Marina S. Ferguson,Kelly L. Hudkins,Christopher D. Benjamin +9 more
TL;DR: The results document the presence of VCAM-1 in human atherosclerosis, demonstrate VCAM1 expression by human smooth muscle cells in vivo, and suggest that intimal neovasculature may be an important site of inflammatory cell recruitment into advanced coronary lesions.